1-Benzyl-4-(4-bromo-phenyl)-pyrrolidine-3-carboxylic acid ethyl ester | 883993-84-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1-Benzyl-4-(4-bromo-phenyl)-pyrrolidine-3-carboxylic acid ethyl ester
• 英文别名: ethyl 1-benzyl-4-(4-bromophenyl)pyrrolidine-3-carboxylate
• CAS: 883993-84-8
• 化学式: C₂₀H₂₂BrNO₂
• 分子量: 388.3
• InChiKey: XVOWKWVSFLHRFU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• ORTHO AMINOAMIDES FOR THE TREATMENT OF CANCER
  申请人：Liang Chungen

  公开号：US20100216806A1

  公开（公告）日：2010-08-26

  Compounds of formula are HDAC inhibitors. These compounds are useful for the treatment of diseases such as cancer in humans or animals.

  这些化合物的化学式是HDAC抑制剂。这些化合物对于治疗人类或动物的癌症等疾病是有用的。
• NOVEL ORTHO-AMINOAMIDES FOR THE TREATMENT OF CANCER
  申请人：F. Hoffmann-La Roche AG

  公开号：EP2398769A1

  公开（公告）日：2011-12-28
• US7977372B2
  申请人：——

  公开号：US7977372B2

  公开（公告）日：2011-07-12
• [EN] NOVEL ORTHO-AMINOAMIDES FOR THE TREATMENT OF CANCER<br/>[FR] NOUVEAUX ORTHO-AMINOAMIDES POUR LE TRAITEMENT DU CANCER
  申请人：HOFFMANN LA ROCHE

  公开号：WO2010094678A1

  公开（公告）日：2010-08-26

  The present invention is directed to the compounds of formula (I) wherein R, R1 and R2 have the significances given herein, to processes for the manufacture of said compounds as well as medicaments containing said compounds. The compounds according to this invention show anti-proliferative and differentiation-inducing activity and are thus useful for the treatment of diseases such as cancer in humans or animals.