5-溴-2-萘胺 | 116400-84-1

• 物质功能分类: 医药中间体 - 原料药中间体
• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 5-溴-2-萘胺
• 英文名称: 5-bromo-2-naphthalamine
• 英文别名: 6-amino-1-bromonaphthalene；5-bromonaphthalen-2-amine；5-bromo-[2]naphthylamine；5-Brom-[2]naphthylamin；5-Brom-2-amino-naphthalin
• CAS: 116400-84-1
• 化学式: C₁₀H₈BrN
• 分子量: 222.084
• InChiKey: UYORWLNZLDKCJS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

制备方法与用途

5-溴-2-萘胺是一种胺类有机化合物，可用于制备医药中间体。

反应信息

• 作为反应物：
  描述：

  5-溴-2-萘胺 在 吡啶 、 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 120.0h， 生成 6-(二丁基氨基)萘-1-腈
  参考文献：
  名称：

  Anellated Hemicyanine Dyes with Large Symmetrical Solvatochromism of Absorption and Fluorescence

  摘要：

  A novel class of amphiphilic hemicyanine dyes is described where electron-pushing aniline and electron-pulling pyridinium are joined by anellated benzene rings. Enhancing the solvent polarity, the absorption band of these ANNINE dyes is shifted to the blue and the fluorescence band is shifted to the red at an invariant 00 energy. The increasing Stokes shift spans the whole visible spectrum. The divergent symmetrical solvatochromism of the positively charged chromophores is parametrized by a monopole-dipole model using a Born-Onsager-Marcus approach. From the intramolecular charge shift that is induced by electronic excitation, the linear Stark effect that is expected when the ANNINE dyes are used as voltage-sensitive probes in a biomembrane is estimated.

  DOI：

  10.1021/jp0345809
• 作为产物：
  描述：

  1-溴-6-硝基萘 在 水 、 铁粉 、 氯化铵 作用下， 以 乙醇 为溶剂， 反应 2.0h， 以1.5 g的产率得到5-溴-2-萘胺
  参考文献：
  名称：

  [EN] COMPOUND FOR TREATING THROMBOTIC DISEASES
  [FR] COMPOSÉ DESTINÉ AU TRAITEMENT DE MALADIES THROMBOTIQUES
  [ZH] 一种治疗血栓性疾病的化合物

  摘要：

  本发明涉及一种治疗血栓性疾病的化合物。具体地，本发明提供一种式I所示的化合物、或其药学上可接受的盐、或其对映异构体、或其非对映异构体、或其阻转异构体、或其外消旋体、或其多晶型物、或其溶剂合物或或其经同位素标记衍生物。本发明所述的化合物能够特异性地与Src激酶的SH3结构域蛋白后，干扰整合素αIIbβ3与Src激酶结合，进而选择性抑制外向内信号转导，不影响内向外信号转导，从而使得本发明的化合物在抗血栓的同时不影响正常的生理性止血功能，避免出血副作用的出现，能够成为新一代预防和治疗血栓相关心脑血管疾病的有效药物。

  公开号：

  WO2022017531A1

文献信息

• 유기전기 소자용 화합물, 이를 이용한 유기전기소자 및 그 전자 장치
  申请人：DUK SAN NEOLUX CO., LTD. 덕산네오룩스 주식회사(120150011099) Corp. No ▼ 161511-0176036BRN ▼312-86-74729

  公开号：KR102109689B1

  公开（公告）日：2020-05-12

  본 발명은 소자의 발광효율, 안정성 및 수명을 향상시킬 수 있는 신규 화합물 및 이를 이용한 유기전기소자, 그 전자 장치를 제공한다.

  本发明提供了一种新型化合物，可提高器件的发光效率、稳定性和寿命，并提供了利用该化合物的有机电子器件和电子装置。
• Synthesis and properties of two PRODAN-based fluorescent models of cholesterol
  作者：Nicholas A. Lopez、Christopher J. Abelt

  DOI：10.1016/j.jphotochem.2012.04.011

  日期：2012.6

  The syntheses and photophysical properties of 1-(5-methylhexyl)-2,3,7,8-tetrahydro-1H-naphtho[2,1-e]indo1-9(6H)-one (7a) and 1-(5-methylhexyl)-23,8,9-terrahydro-1H-naphrho[2,1-e]indol-6(7H)-one (7b) are reported. They are prepared in eight steps from the corresponding bromonaphthylamines. These fluorescent compounds have PRODAN-like cores, and they are structurally similar to cholesterol. Compound 7a is the first reported PRODAN derivative where both the amino and carbonyl groups are constrained to be coplanar with the naphthalene core. Comparing the photophysical behavior of these compounds with related compounds indicates that locking the amino group in a five-membered ring enhances their desirable properties as solvent polarity sensors. (C) 2012 Elsevier B.V. All rights reserved.
• v. Braun; Hahn; Seemann, Chemische Berichte, 1922, vol. 55, p. 1694
  作者：v. Braun、Hahn、Seemann

  DOI：——

  日期：——
• Synthesis and spectral characterization of bisnaphthylmethyl and trinaphthylmethyl cations
  作者：Lionel Sanguinet、Robert J. Twieg、Greg Wiggers、Guilin Mao、Kenneth D. Singer、Rolfe G. Petschek

  DOI：10.1016/j.tetlet.2005.05.138

  日期：2005.8

  Cationic triarylmethane dyes containing one, two or three naphthalene moieties have been prepared. Their synthesis and preliminary spectral, nonlinear optical and theoretical characterization tire reported here. The major electronic and steric hindrance effects of the 1.4-linked naphthalene have been examined by comparison of the UV-vis absorption of the 1,4-linked and 2,6-linked series. (c) 2005 Elsevier Ltd. All rights reserved.
• The Synthesis of 3-Substituted Derivatives of Methylcholanthrene
  作者：Louis F. Fieser、Byron Riegel

  DOI：10.1021/ja01291a023

  日期：1937.12