4-(2-chloro-9-methyl-8-(pyridin-4-yl)-9H-purin-6-yl)morpholine 、
4-methyl-2-(1H-pyrazol-3-yl)morpholine 在
caesium carbonate 作用下,
以
N,N-二甲基甲酰胺 为溶剂,
以22 %的产率得到4-methyl-2-(1-(9-methyl-6-morpholino-8-(pyridin-4-yl)-9H-purin-2-yl)-1H-pyrazol-3-yl)morpholine