(2R,3S)-2-(hydroxymethyl)-4-methyloxolan-3-ol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧唑烯
• 英文名称: (2R,3S)-2-(hydroxymethyl)-4-methyloxolan-3-ol
• 化学式: C₆H₁₂O₃
• 分子量: 132.16
• InChiKey: RKSJJUOPDBHSGU-UVCATTPVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  49.7
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• NOVEL AZABENZIMIDAZOLE TETRAHYDROFURAN DERIVATIVES
  申请人：Merck Sharp & Dohme Corp.

  公开号：US20150203487A1

  公开（公告）日：2015-07-23

  Novel compounds of the structural formula (I) are activators of AMP-protein kinase and may be useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention may be useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.

  结构式（I）的新化合物是AMP-蛋白激酶的激活剂，可能在治疗、预防和抑制由AMPK激活的蛋白激酶介导的疾病中有用。本发明的化合物可能在治疗2型糖尿病、高血糖、代谢综合征、肥胖、高胆固醇和高血压方面有用。
• NOVEL BENZIMIDAZOLE TETRAHYDROFURAN DERIVATIVES
  申请人：Merck Sharp & Dohme Corp.

  公开号：US20150218149A1

  公开（公告）日：2015-08-06

  Novel compounds of the structural formula (I) are activators of AMP-protein kinase and may be useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention may be useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.

  结构式(I)的新化合物是AMP-蛋白激酶的激活剂，可能在治疗、预防和抑制由AMPK激活的蛋白激酶介导的疾病方面有用。本发明的化合物可能在治疗2型糖尿病、高血糖、代谢综合征、肥胖、高胆固醇血症和高血压方面有用。
• US9540364B2
  申请人：——

  公开号：US9540364B2

  公开（公告）日：2017-01-10
• [EN] NOVEL BENZIMIDAZOLE TETRAHYDROFURAN DERIVATIVES<br/>[FR] NOUVEAUX DÉRIVÉS DE BENZIMIDAZOLE TÉTRAHYDROFURANE UTILES EN TANT QU'ACTIVATEURS DE LA PROTÉINE KINASE ACTIVÉE PAR L'AMP
  申请人：MERCK SHARP & DOHME

  公开号：WO2014031441A1

  公开（公告）日：2014-02-27

  Novel compounds of the structural formula (I) are activators of AMP-protein kinase and may be useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention may be useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.
• [EN] NOVEL AZABENZIMIDAZOLE TETRAHYDROFURAN DERIVATIVES<br/>[FR] NOUVEAUX DÉRIVÉS D'AZABENZIMIDAZOLE TÉTRAHYDROFURANE
  申请人：MERCK SHARP & DOHME

  公开号：WO2014031517A1

  公开（公告）日：2014-02-27

  Novel compounds of the structural formula (I) are activators of AMP-protein kinase and may be useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention may be useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.