2-Tert-butyl-4-chloro-5-[4-[4-(imidazol-1-ylmethyl)phenyl]but-3-ynoxy]pyridazin-3-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-Tert-butyl-4-chloro-5-[4-[4-(imidazol-1-ylmethyl)phenyl]but-3-ynoxy]pyridazin-3-one
• 英文别名: 2-tert-butyl-4-chloro-5-[4-[4-(imidazol-1-ylmethyl)phenyl]but-3-ynoxy]pyridazin-3-one
• 化学式: C₂₂H₂₃ClN₄O₂
• 分子量: 410.9
• InChiKey: PIHQGSKTBNPXIN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  59.7
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• COMPOSITIONS, METHODS, AND SYSTEMS FOR THE SYNTHESIS AND USE OF IMAGING AGENTS
  申请人：Lantheus Medical Imaging, Inc.

  公开号：US20150196672A1

  公开（公告）日：2015-07-16

  The present invention provides compounds with imaging moieties for imaging a subject. The present invention also relates to systems, compositions, and methods for the synthesis and use of imaging agents, or precursors thereof. An imaging agent precursor may be converted to an imaging agent using the methods described herein. In some cases, a composition or plurality of imaging agents is enriched in 18 F. In some cases, an imaging agent may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs.

  本发明提供了具有成像基团的化合物，用于对受试者进行成像。本发明还涉及用于合成和使用成像试剂或其前体的系统、组合物和方法。成像试剂前体可以使用本文所述的方法转化为成像试剂。在某些情况下，组合物或多种成像试剂富集于 18 F。在某些情况下，成像试剂可用于成像受试者的感兴趣区域，包括但不限于心脏、心血管系统、心脏血管、大脑和其他器官。
• US9713651B2
  申请人：——

  公开号：US9713651B2

  公开（公告）日：2017-07-25
• [EN] COMPOSITIONS, METHODS, AND SYSTEMS OF THE SYNTHESIS AND USE OF IMAGING AGENTS<br/>[FR] COMPOSITIONS, PROCÉDÉS ET SYSTÈMES DE SYNTHÈSE, ET UTILISATION D'AGENTS D'IMAGERIE
  申请人：LANTHEUS MEDICAL IMAGING INC

  公开号：WO2014026079A2

  公开（公告）日：2014-02-13

  The present invention provides compounds with imaging moieties for imaging a subject. The present invention also relates to systems, compositions, and methods for the synthesis and use of imaging agents, or precursors thereof. An imaging agent precursor may be converted to an imaging agent using the methods described herein. In some cases, a composition or plurality of imaging agents is enriched in 18 F. In some cases, an imaging agent may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs.