Preparation of 2-(tert-butyl)-4-chloro-5-((4-((2-fluoroethoxy)methyl)phenyl)ethynyl)pyridazin-3(2H)-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Preparation of 2-(tert-butyl)-4-chloro-5-((4-((2-fluoroethoxy)methyl)phenyl)ethynyl)pyridazin-3(2H)-one
• 英文别名: 2-tert-butyl-4-chloro-5-[2-[4-(2-fluoroethoxymethyl)phenyl]ethyl]pyridazin-3-one
• 化学式: C₁₉H₂₄ClFN₂O₂
• 分子量: 366.863
• InChiKey: QRNHOYQIPQQPSM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  25
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  41.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-((4-(2-(1-(tert-butyl)-5-chloro-6-oxo-1,6-dihydropyridazin-4-yl)ethyl)benzyl)oxy)ethyl 4-methylbenzenesulfonate 在 Lindlar's catalyst 、 氢气 作用下， 以 正己烷 、 乙酸乙酯 为溶剂， 以4 g的产率得到Preparation of 2-(tert-butyl)-4-chloro-5-((4-((2-fluoroethoxy)methyl)phenyl)ethynyl)pyridazin-3(2H)-one
  参考文献：
  名称：

  JP2015531760A5

  摘要：

  公开号：

  JP2015531760A5

文献信息

• COMPOSITIONS, METHODS, AND SYSTEMS FOR THE SYNTHESIS AND USE OF IMAGING AGENTS
  申请人：Lantheus Medical Imaging, Inc.

  公开号：US20150196672A1

  公开（公告）日：2015-07-16

  The present invention provides compounds with imaging moieties for imaging a subject. The present invention also relates to systems, compositions, and methods for the synthesis and use of imaging agents, or precursors thereof. An imaging agent precursor may be converted to an imaging agent using the methods described herein. In some cases, a composition or plurality of imaging agents is enriched in 18 F. In some cases, an imaging agent may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs.

  本发明提供了具有成像基团的化合物，用于对受试者进行成像。本发明还涉及用于合成和使用成像试剂或其前体的系统、组合物和方法。成像试剂前体可以使用本文所述的方法转化为成像试剂。在某些情况下，组合物或多种成像试剂富集于 18 F。在某些情况下，成像试剂可用于成像受试者的感兴趣区域，包括但不限于心脏、心血管系统、心脏血管、大脑和其他器官。
• APPARATUS FOR SYNTHESIZING THE IMAGING AGENT 4-CHLORO-2-(1,1-DIMETHYLETHYL)-5-[[4-[[2-(FLUORO-[18F])ETHOXY]METHYL]PHENYL]METHOXY]-3(2H)-PYRIDAZINONE (FLUORPIRIDAZ [18F])
  申请人：Lantheus Medical Imaging, Inc.

  公开号：EP3653621A1

  公开（公告）日：2020-05-20

  An apparatus for synthesizing the imaging agent of the formula comprising a cassette as shown in Figure 17 with a linear arrangement of a plurality of stopcock manifolds arranged in the order: 1) luer connections to gas inlet and [18O]H2O recovery; 2) anion exchange cartridge - column eluting solution; 3) spike connection for acetonitrile; 4) empty syringe; 5) reservoir with solution of imaging agent precursor; 6) reaction vessel; 7) outlet to HPLC; 8) syringe with solution of a stabilizing agent; 9) inlet from HPLC; 10) ethanol reservoir; 11) syringe with solution of a stabilizing agent; 12) syringe with water; 13) final product vial; 14) empty syringe; and 15) reaction vessel and exhaust; further comprising tubing, an imaging agent synthesis module, wherein the apparatus is fluidically connected to the apparatus, and wherein the solution of a stabilizing agent comprises a solution comprising ascorbic acid or a salt thereof.

  一种合成式中成像剂的装置 包括一个如图 17 所示的盒体，盒体上直线排列着多个按顺序排列的截止阀歧管： 1）气体入口和[18O]H2O 回收的鲁尔接头； 2) 阴离子交换滤芯-柱洗脱液； 3) 用于乙腈的尖头连接； 4) 空注射器 5) 装有成像剂前体溶液的容器； 6) 反应容器 7) 连接 HPLC 的出口； 8) 装有稳定剂溶液的注射器； 9) 高效液相色谱仪的入口 10）乙醇储液器 11) 装有稳定剂溶液的注射器； 12) 装有水的注射器 13) 最终产品小瓶 14) 空注射器；以及 15) 反应容器和排气管； 进一步包括管道、成像剂合成模块，其中该装置与该设备流体连接，稳定剂溶液包括由抗坏血酸或其盐组成的溶液。
• Compositions, methods, and systems for the synthesis and use of imaging agents
  申请人：Lantheus Medical Imaging, Inc.

  公开号：US10500293B2

  公开（公告）日：2019-12-10

  The present invention provides compounds with imaging moieties for imaging a subject. The present invention also relates to systems, compositions, and methods for the synthesis and use of imaging agents, or precursors thereof. An imaging agent precursor may be converted to an imaging agent using the methods described herein. In some cases, a composition or plurality of imaging agents is enriched in 18F. In some cases, an imaging agent may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs.

  本发明提供了具有成像分子的化合物，用于对主体成像。本发明还涉及成像剂或其前体的合成和使用系统、组合物和方法。成像剂前体可通过本文所述方法转化为成像剂。在某些情况下，成像剂组合物或多种成像剂富含 18F。在某些情况下，成像剂可用于成像受试者感兴趣的区域，包括但不限于心脏、心血管系统、心脏血管、大脑和其他器官。
• PYRIDAZIN-3(2H)-ONE DERIVATIVES AS IMAGING AGENTS FOR DETECTING MYOCARDIAL PERFUSION
  申请人：Lantheus Medical Imaging, Inc.

  公开号：EP2882719B1

  公开（公告）日：2019-10-09
• US9713651B2
  申请人：——

  公开号：US9713651B2

  公开（公告）日：2017-07-25