6-ethynyl-N-methylpyridazin-3-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 6-ethynyl-N-methylpyridazin-3-amine
• 化学式: C₇H₇N₃
• 分子量: 133.15
• InChiKey: VCCNQLLCIHJQFA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  37.8
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Protein Kinase Inhibitors
  申请人：ASTAR BIOTECH LLC

  公开号：US20140364436A1

  公开（公告）日：2014-12-11

  The present invention relates to compounds of Formula VIII with absolute configuration R or S: as well as pharmaceutically acceptable salts, hydrates, or solvates thereof, wherein the variables are described herein. The present invention further relates to pharmaceutical compositions which comprise the compounds of Formula VIII, and to methods for inhibiting protein kinase and methods of treating diseases, such as cancers, inflammation.

  本发明涉及具有绝对构型R或S的VIII式化合物，以及其药学上可接受的盐、水合物或溶剂化物，其中变量在此描述。本发明还涉及包括VIII式化合物的制药组合物，以及抑制蛋白激酶的方法和治疗疾病的方法，例如癌症、炎症等。
• US9174996B2
  申请人：——

  公开号：US9174996B2

  公开（公告）日：2015-11-03
• [EN] PROTEIN KINASE INHIBITORS<br/>[FR] INHIBITEURS DE PROTÉINES KINASES
  申请人：ASTAR BIOTECH LLC

  公开号：WO2014019338A1

  公开（公告）日：2014-02-06

  Disclosed are compounds of Formula I, as well as pharmaceutically acceptable salts, hydrates, isomers, or solvates thereof. Also disclosed are pharmaceutical compositions which comprise the compounds of Formula I, and methods for inhibiting protein kinase and methods of treating diseases, such as cancers, inflammation.
• [EN] PROTEIN KINASE INHIBITORS<br/>[FR] INHIBITEURS DE PROTÉINE KINASE
  申请人：ASTAR BIOTECH LLC

  公开号：WO2016029776A1

  公开（公告）日：2016-03-03

  The compounds of Formula (VIII) with absolute configuration R or S, as well as pharmaceutically acceptable salts, hydrates, or solvates thereof, wherein the variables are described herein. The pharmaceutical compositions which comprise the compounds of Formula (VIII), and methods for inhibiting protein kinase and methods of treating diseases, such as cancers, inflammation are provided.