6-methoxy-2,5-dimethyl-1-oxo-1,2,3,4-tetrahydro-[2]naphthoic acid methyl ester | 101089-19-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 6-methoxy-2,5-dimethyl-1-oxo-1,2,3,4-tetrahydro-[2]naphthoic acid methyl ester
• 英文别名: 6-Methoxy-2,5-dimethyl-1-oxo-1,2,3,4-tetrahydro-[2]naphthoesaeure-methylester；Methyl 6-methoxy-2,5-dimethyl-1-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylate, AldrichCPR；methyl 6-methoxy-2,5-dimethyl-1-oxo-3,4-dihydronaphthalene-2-carboxylate
• CAS: 101089-19-4
• 化学式: C₁₅H₁₈O₄
• 分子量: 262.306
• InChiKey: GLNQCQVWAVVUAE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6-methoxy-2,5-dimethyl-1-oxo-1,2,3,4-tetrahydro-[2]naphthoic acid methyl ester 在 palladium on activated charcoal 氢氧化钾 、 氢气 、 N,N'-二环己基碳二亚胺 作用下， 以 乙醇 、 溶剂黄146 、 乙酸乙酯 为溶剂， 生成 6-Benzyloxy-2,5-dimethyl-1,2,3,4-tetrahydro-naphthalin-2-carbonsaeure-phenylester
  参考文献：
  名称：

  Pollini,G.P. et al., Farmaco, Edizione Scientifica, 1966, vol. 21, p. 818 - 828

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 sodium methylate 、 苯 作用下， 生成 6-methoxy-2,5-dimethyl-1-oxo-1,2,3,4-tetrahydro-[2]naphthoic acid methyl ester
  参考文献：
  名称：

  Experimental laser destruction of trigeminal sensory root

  摘要：

  The possibility of local laser destruction of the trigeminal sensory root by a puncture technique is demonstrated. A fibrous scar was formed on a limited area of the trigeminal root. There were no signs of axonal regeneration, posttraumatic neuroma, or considerable changes in the Meekel sinus.

  DOI：

  10.1007/bf02434888

文献信息

• Steroids and related compounds—I
  作者：M.J. Temple Robinson

  DOI：10.1016/0040-4020(57)85010-8

  日期：1957.1

  Starting with 6-methoxy-5-methyltetralin (I), several routes to the compound (XXI) named in the title have been developed. The tetralin (I) was converted into the hexahydrophenanthrene (X) and some attempts were made to convert the latter into a 2:3-glycol or related compound with a view to changing the potential homo-D-ring into a natural D-ring before reducing the 4:12-double bond. The ketone (X)

  从6-甲氧基-5-甲基四氢萘酚（I）开始，已经开发了几种获得标题名称的化合物（XXI）的途径。将四氢化萘（I）转化为六氢菲（X），并进行了一些尝试，将后者转变为2：3-乙二醇或相关化合物，以期将潜在的均D-环转变为天然D-环在减少4：12-双键之前。通过三阶段甲基化和一，二或三阶段还原，将酮（X）转化为所需产物（XXI），改变反应的顺序以获得结构和空间特异性。当试图预测并随后合理化减少的空间过程时，发现催化剂阻碍的概念1设置在比哈德勒的构象参数的更好的引导件，其最初被施加到Δ 4 -和Δ 5个-steroids。2个
• 397. Experiments on the synthesis of substances related to the sterols. Part XLIX. The A ? BCD route to androstenedione. Part II
  作者：R. H. Martin、Robert Robinson

  DOI：10.1039/jr9490001866

  日期：——
• Experimental laser destruction of trigeminal sensory root
  作者：R. U. Giniatullin、A. I. Kozel'、S. T. Ismagilova

  DOI：10.1007/bf02434888

  日期：2000.6

  The possibility of local laser destruction of the trigeminal sensory root by a puncture technique is demonstrated. A fibrous scar was formed on a limited area of the trigeminal root. There were no signs of axonal regeneration, posttraumatic neuroma, or considerable changes in the Meekel sinus.
• Pollini,G.P. et al., Farmaco, Edizione Scientifica, 1966, vol. 21, p. 818 - 828
  作者：Pollini,G.P. et al.

  DOI：——

  日期：——