N-(2-chloropyrimidin-4-yl)-1-methyl-benzimidazol-4-amine | 1582752-18-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: N-(2-chloropyrimidin-4-yl)-1-methyl-benzimidazol-4-amine
• 英文别名: N-(2-chloropyrimidin-4-yl)-1-methylbenzimidazol-4-amine
• CAS: 1582752-18-8
• 化学式: C₁₂H₁₀ClN₅
• 分子量: 259.698
• InChiKey: WJRDFHMSZINVCX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  55.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• 4-(Indolyl or benzimidazolyl)amino-2-(2-(indol-3-yl)ethyl)aminopyrimidines useful for the treatment of cancer
  申请人：Chemilia AB

  公开号：EP2711364A1

  公开（公告）日：2014-03-26

  The invention provides novel indole- and benzimidazole-substituted diaminopyrimidines of formula I, to methods of preparing such compounds, to pharmaceutical compositions containing such compounds, and to methods for using such compounds in treatment of diseases including cancer; wherein R1-R3 are as defined in the specification.

  该发明提供了新型的公式I的吲哚和苯并咪唑取代的二氨基嘧啶化合物，以及制备这些化合物的方法，含有这些化合物的药物组合物，以及使用这些化合物治疗包括癌症在内的疾病的方法；其中R1-R3如规范中所定义。
• 4-(INDOLYL OR BENZIMIDAZOLYL)AMINO-2-(2-(INDOL-3-YL)ETHYL)AMINOPYRIMIDINES USEFUL FOR THE TREATMENT OF CANCER
  申请人：NOVIGA RESEARCH AB

  公开号：US20150252026A1

  公开（公告）日：2015-09-10

  The invention provides novel indole-and benzimidazole-substituted diaminopyrimidines of formula I, to methods of preparing such compounds, to pharmaceutical compositions containing such compounds, and to methods for using such compounds treatment of diseases including cancer; wherein R 1 -R 3 are as defined in the specification.