3,5-diamino-6-chloro-N-[N'-[(3S)-1-[[6-(trifluoromethyl)pyridin-3-yl]methyl]-1-azoniabicyclo[2.2.2]octan-3-yl]carbamimidoyl]pyrazine-2-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 3,5-diamino-6-chloro-N-[N'-[(3S)-1-[[6-(trifluoromethyl)pyridin-3-yl]methyl]-1-azoniabicyclo[2.2.2]octan-3-yl]carbamimidoyl]pyrazine-2-carboxamide
• 化学式: C20H24ClF3N9O+
• 分子量: 498.9
• InChiKey: JBOGOYJHBXIIQZ-VGKUZZGFSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  34
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  158
• 氢给体数：
  4
• 氢受体数：
  10

文献信息

• HETEROCYCLIC COMPOUNDS, MEDICAMENTS CONTAINING SAID COMPOUNDS, USE THEREOF AND PROCESSES FOR THE PREPARATION THEREOF
  申请人：Boehringer Ingelheim International GmbH

  公开号：EP2897940B1

  公开（公告）日：2019-05-01
• ORGANIC ELECTROLUMINESCENCE DEVICE
  申请人：TAKADA Saki

  公开号：US20110073848A1

  公开（公告）日：2011-03-31

  A material for a light emitting device containing a compound represented by the following formula (1): wherein each A independently represents a nitrogen atom or a carbon atom, which may have a substituent, and each of the rings consisting of A and nitrogen atoms independently represents an aromatic ring or an aromatic heterocyclic ring; and L represents a divalent linking group.
• US8841309B2
  申请人：——

  公开号：US8841309B2

  公开（公告）日：2014-09-23
• [EN] HETEROCYCLIC COMPOUNDS, MEDICAMENTS CONTAINING SAID COMPOUNDS, USE THEREOF AND PROCESSES FOR THE PREPARATION THEREOF<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES, MÉDICAMENTS CONTENANT CES COMPOSÉS, LEUR UTILISATION ET PROCÉDÉS DE LEUR PRÉPARATION
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2014044849A1

  公开（公告）日：2014-03-27

  The present invention relates to compounds of general formula (I), and the tautomers and the salts thereof, particularly the pharmaceutically acceptable salts thereof, which have valuable pharmacological properties, particularly an inhibitory effect on epithelial sodium channels, the use thereof for the treatment of diseases, particularly diseases of the lungs and airways.