Ethyl 4-[[1-[(2-methylpropan-2-yl)oxycarbonyl]piperidin-4-yl]amino]pyrimidine-2-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: Ethyl 4-[[1-[(2-methylpropan-2-yl)oxycarbonyl]piperidin-4-yl]amino]pyrimidine-2-carboxylate
• 英文别名: ethyl 4-[[1-[(2-methylpropan-2-yl)oxycarbonyl]piperidin-4-yl]amino]pyrimidine-2-carboxylate
• 化学式: C₁₇H₂₆N₄O₄
• 分子量: 350.4
• InChiKey: ONZAJHCHAPBWRX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  93.6
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• NOVEL THERAPEUTICS FOR BRAIN CANCER
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US20150259326A1

  公开（公告）日：2015-09-17

  Provided herein are novel compositions and methods to inhibit Olig2 activity. The Olig2 inhibitors and methods of using the same are useful, inter alia, for treating cancer. In particular the Olig2 inhibitors may be used to treat glioblastoma. Further, provided are peptide compositions capable of inhibiting Olig 2.
• [EN] NOVEL THERAPEUTICS FOR BRAIN CANCER<br/>[FR] NOUVEAUX AGENTS THÉRAPEUTIQUES POUR LE CANCER DU CERVEAU
  申请人：UNIV CALIFORNIA

  公开号：WO2013188813A2

  公开（公告）日：2013-12-19

  Provided herein are novel compositions and methods to inhibit Olig2 activity. The Olig2 inhibitors and methods of using the same are useful, inter alia, for treating cancer. In particular the Olig2 inhibitors may be used to treat glioblastoma. Further, provided are peptide compositions capable of inhibiting Olig 2.