7-Amino-9-fluoro-4-methyl-5,7-dihydrobenzo[d][1]benzazepin-6-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: 7-Amino-9-fluoro-4-methyl-5,7-dihydrobenzo[d][1]benzazepin-6-one
• 英文别名: 7-amino-9-fluoro-4-methyl-5,7-dihydrobenzo[d][1]benzazepin-6-one
• 化学式: C₁₅H₁₃FN₂O
• 分子量: 256.27
• InChiKey: LMAFZFGMIRVXOJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  19
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• FLUOROALKYL DIBENZOAZEPINONE COMPOUNDS
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20150218104A1

  公开（公告）日：2015-08-06

  Disclosed are compounds of Formula (I): wherein R 1 is CH 2 CH2CF 3 or CH 2 CH2CH 3 ; R2 is CH 2 CH 2 CF 3 , CH 2 CH 2 CH 3 , CH 2 (cyclopropyl), phenyl, or; R3 is H; R a , R b , y, and z are defined herein. Also disclosed are methods of using such compounds to inhibit the Notch receptor, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as cancer.

  本发明涉及化合物的公式(I)： 其中R1为 CF3或 CH3；R2为 CF3， CH3，CH2（环丙基），苯基或；R3为H；Ra，Rb，y和z在此定义。还公开了使用这种化合物来抑制Notch受体的方法以及包含这种化合物的制药组合物。这些化合物在治疗、预防或减缓多种治疗领域中的疾病或障碍方面非常有用，例如癌症。
• FLUOROALKYL DIBENZODIAZEPINONE COMPOUNDS
  申请人：Bristol-Myers Squibb Company

  公开号：EP2897938A1

  公开（公告）日：2015-07-29
• US9133126B2
  申请人：——

  公开号：US9133126B2

  公开（公告）日：2015-09-15
• [EN] FLUOROALKYL DIBENZODIAZEPINONE COMPOUNDS<br/>[FR] COMPOSÉS FLUOROALKYL BENZODIAZÉPINONES
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2014047370A1

  公开（公告）日：2014-03-27

  Disclosed are compounds of Formula (I): wherein R1 is CH2CH2CF3 or CH2CH2CH3; R2 is CH2CH2CF3, CH2CH2CH3, CH2(cyclopropyl), phenyl, or; R3 is H; Ra, Rb, y, and z are defined herein. Also disclosed are methods of using such compounds to inhibit the Notch receptor, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as cancer.