2,4-Diamino-6-cyclohexylpyrimidine-5-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2,4-Diamino-6-cyclohexylpyrimidine-5-carboxamide
• 英文别名: 2,4-diamino-6-cyclohexylpyrimidine-5-carboxamide
• 化学式: C₁₁H₁₇N₅O
• 分子量: 235.29
• InChiKey: HZOUINAFOSJBKZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  121
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• [EN] 2-(2-AMINOCYCLOHEXYL)AMINO-PYRIMIDINE-5-CARBOXAMIDES AS SPLEEN TYROSINE KINASEI(SYK) INHIBITORS<br/>[FR] 2-(2-AMINOCYCLOHEXYL)AMINOPYRIMIDINO-5-CARBOXAMIDES UTILISÉS COMME INHIBITEURS DE LA SPLEEN TYROSINE KINASE (SYK)
  申请人：ZIARCO PHARMA LTD

  公开号：WO2014045029A1

  公开（公告）日：2014-03-27

  The present invention relates to compounds of formula (Ia), (Ib) or (Ic): to pharmaceutically acceptable salts therefore and to pharmaceutically acceptable solvates of said compounds and salts, wherein the substituents are defined herein; to compositions containing such compounds; and to the uses of such compounds in the treatment of various diseases, particularly asthma, COPD, allergic rhinitis, chronic sinusitis, atopic dermatitis, psoriasis, rosacea, alopecia, allergic conjunctivitis and dry eye disease

  本发明涉及公式（Ia），（Ib）或（Ic）的化合物：其药学上可接受的盐和所述化合物和盐的药学上可接受的溶剂，其中所述取代基在此处定义；含有这些化合物的组合物；以及在治疗各种疾病，特别是哮喘，慢性阻塞性肺疾病，过敏性鼻炎，慢性鼻窦炎，特应性皮炎，银屑病，酒渣鼻，脱发，过敏性结膜炎和干眼病中使用这些化合物的用途。
• Pyrimidine-5-carboxamides as spleen tyrosine kinase inhibitors
  申请人：Ziarco Pharma Ltd.

  公开号：US10065964B2

  公开（公告）日：2018-09-04

  The present invention relates to compounds of formula (Ia), (Ib) or (Ic): to pharmaceutically acceptable salts therefore and to pharmaceutically acceptable solvates of said compounds and salts, wherein the substituents are defined herein; to compositions containing such compounds; and to the uses of such compounds in the treatment of various diseases, particularly asthma, COPD, allergic rhinitis, chronic sinusitis, atopic dermatitis, psoriasis, rosacea, alopecia, allergic conjunctivitis and dry eye disease.

  本发明涉及式 (Ia)、(Ib) 或 (Ic) 的化合物： 以及上述化合物和盐的药学上可接受的盐和药学上可接受的溶液，其中取代基在本文中定义；涉及含有此类化合物的组合物；以及此类化合物在治疗各种疾病中的用途，尤其是哮喘、慢性阻塞性肺病、过敏性鼻炎、慢性鼻窦炎、特应性皮炎、银屑病、酒渣鼻、脱发、过敏性结膜炎和干眼病。
• 2-(2-AMINOCYCLOHEXYL)AMINO-PYRIMIDINE-5-CARBOXAMIDES AS SPLEEN TYROSINE KINASEI(SYK) INHIBITORS
  申请人：Ziarco Pharma Ltd

  公开号：EP2897950A1

  公开（公告）日：2015-07-29
• 2-(2-AMINOCYCLOHEXYL)AMINO-PYRIMIDINE-5-CARBOXAMIDES AS SPLEEN TYROSINE KINASE(SYK) INHIBITORS
  申请人：Ziarco Pharma Ltd.

  公开号：US20170145019A1

  公开（公告）日：2017-05-25

  The present invention relates to compounds of formula (Ia), (Ib) or (Ic): to pharmaceutically acceptable salts therefore and to pharmaceutically acceptable solvates of said compounds and salts, wherein the substituents are defined herein; to compositions containing such compounds; and to the uses of such compounds in the treatment of various diseases, particularly asthma, COPD, allergic rhinitis, chronic sinusitis, atopic dermatitis, psoriasis, rosacea, alopecia, allergic conjunctivitis and dry eye disease.
• US9533989B2
  申请人：——

  公开号：US9533989B2

  公开（公告）日：2017-01-03