1-[5-[4-Bromo-1-(2,2-dimethylpropyl)benzotriazol-5-yl]pyridin-2-yl]ethanone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并三唑类
• 英文名称: 1-[5-[4-Bromo-1-(2,2-dimethylpropyl)benzotriazol-5-yl]pyridin-2-yl]ethanone
• 英文别名: 1-[5-[4-bromo-1-(2,2-dimethylpropyl)benzotriazol-5-yl]pyridin-2-yl]ethanone
• 化学式: C₁₈H₁₉BrN₄O
• 分子量: 387.3
• InChiKey: VMBCDWYKWBCTQB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  60.7
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• CYCLOHEXENE BENZOTRIAZOLE DERIVATIVES
  申请人：Beshore Douglas C.

  公开号：US20140088150A1

  公开（公告）日：2014-03-27

  The present invention is directed to cyclohexene benzotriazole derivatives which are potentiators of metabotropic glutamate receptors, particularly the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.

  本发明涉及环己烯苯并三唑衍生物，它们是代谢型谷氨酸受体增效剂，特别是mGluR2受体，可用于治疗或预防与谷氨酸功能障碍相关的神经和精神障碍以及代谢型谷氨酸受体参与的疾病。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗代谢型谷氨酸受体参与的疾病中的使用。
• US8785482B2
  申请人：——

  公开号：US8785482B2

  公开（公告）日：2014-07-22