2-pyridin-4-yl-4,5-dihydro-1H-pyrimidin-6-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-pyridin-4-yl-4,5-dihydro-1H-pyrimidin-6-one
• 化学式: C₉H₉N₃O
• 分子量: 175.19
• InChiKey: LWZBRDHTBAGDDK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] PREPARATION AND USES OF PYRIMIDINONE DERIVATIVES<br/>[FR] PRÉPARATION ET UTILISATIONS DE DÉRIVÉS DE PYRIMIDINONE
  申请人：CANCER RESEARCH TECH LTD

  公开号：WO2018055402A1

  公开（公告）日：2018-03-29

  The present invention relates to compounds of formula (I), and salts and solvates thereof, that function as inhibitors of cell division cycle 7 (Cdc7) kinase enzyme activity: (Formula (I)) wherein X, R1, R2, and n are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which Cdc7 kinase activity is implicated.

  本发明涉及式(I)的化合物，以及其盐和溶剂合物，其作为细胞分裂周期7（Cdc7）激酶酶活性的抑制剂：（式(I)）其中X，R1，R2和n如本文所定义。本发明还涉及制备这些化合物的方法，包括它们的药物组合物，以及它们在治疗增殖性疾病（如癌症）以及其他涉及Cdc7激酶活性的疾病或病况中的用途。
• PREPARATION AND USES OF PYRIMIDINONE DERIVATIVES
  申请人：Cancer Research Technology Limited

  公开号：EP3515903B1

  公开（公告）日：2020-10-21
• LIBRARIES OF COMPOUNDS HAVING DESIRED PROPERTIES AND METHODS FOR MAKING AND USING THEM
  申请人：BIOBLOCKS, INC.

  公开号：US20150269356A1

  公开（公告）日：2015-09-24

  In alternative embodiments the invention provides libraries of compounds, or drugs or drug candidates, manufactured and selected for having a desired property such as a biological or a chemical activity, and methods for making and using them. In one embodiment, the invention provides methods for identifying desirable compounds from very large compound sets using a compound fragment as the query. In alternative embodiments, the invention provides methods of making compounds, and libraries of compounds, using a “feasible reaction” growth scheme.
• US9946847B2
  申请人：——

  公开号：US9946847B2

  公开（公告）日：2018-04-17
• [EN] LIBRARIES OF COMPOUNDS HAVING DESIRED PROPERTIES AND METHODS FOR MAKING AND USING THEM<br/>[FR] BANQUES DE COMPOSÉS AYANT DES PROPRIÉTÉS SOUHAITÉES ET PROCÉDÉS DE FABRICATION ET D'UTILISATION ASSOCIÉS
  申请人：BIOBLOCKS INC

  公开号：WO2014047463A2

  公开（公告）日：2014-03-27

  In alternative embodiments the invention provides libraries of compounds, or drugs or drug candidates, manufactured and selected for having a desired property such as a biological or a chemical activity, and methods for making and using them. In one embodiment, the invention provides methods for identifying desirable compounds from very large compound sets using a compound fragment as the query. In alternative embodiments, the invention provides methods of making compounds, and libraries of compounds, using a "feasible reaction" growth scheme.