5-hydroxy-4-propan-2-yl-1H-pyrimidin-6-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5-hydroxy-4-propan-2-yl-1H-pyrimidin-6-one
• 化学式: C₇H₁₀N₂O₂
• 分子量: 154.17
• InChiKey: SVMWRGKLBOKMKM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  61.7
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• CEPHEM COMPOUND HAVING PYRIDINIUM GROUP
  申请人：Nishitani Yasuhiro

  公开号：US20140114060A1

  公开（公告）日：2014-04-24

  The present invention provides a novel compound which has a broad antibacterial spectrum and particularly exhibits a high antibacterial activity on β-lactamase-producing gram-negative bacteria. Specifically provided are: a compound represented by formula (I) wherein the meaning of each symbol is as defined in the description, an amino-group-protected form of a type of the compound which has the amino group on a ring in a position-7 side chain, or a pharmaceutically acceptable salt of the compound or the amino-group-protected form; and a pharmaceutical composition containing the compound, the amino-group-protected form or the pharmaceutically acceptable salt.

  本发明提供了一种新型化合物，具有广泛的抗菌谱，特别对产β-内酰胺酶的革兰氏阴性细菌表现出高抗菌活性。具体提供的是：一种由式(I)表示的化合物，其中每个符号的含义如描述中定义的那样，一种在环上具有氨基团的化合物的保护形式，该化合物在位置-7侧链上具有氨基团，或者化合物或氨基团保护形式的药用可接受盐；以及含有该化合物、氨基团保护形式或药用可接受盐的药物组合物。
• ANTIBACTERIAL COMPOUNDS
  申请人：Forge Therapeutics, Inc.

  公开号：US20210221796A1

  公开（公告）日：2021-07-22

  Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting the growth of gram-negative bacteria. Furthermore, the subject compounds and compositions are useful for the treatment of bacterial infection, such as urinary tract infection and the like.

  本文提供的是杂环衍生物化合物和包含这些化合物的药物组合物，其对抑制革兰氏阴性菌的生长非常有用。此外，这些化合物和组合物还可用于治疗细菌感染，如尿路感染等。
• 2-SUBSTITUTED CEPHEM COMPOUNDS
  申请人：GLAXO GROUP LIMITED

  公开号：US20150299223A1

  公开（公告）日：2015-10-22

  The present invention relates to 2-substituted cephem compounds of Formula (I) having a quaternary ammonium group on the 3-side chain, preferably together with a cathechol group, or pharmaceutically acceptable salts thereof, which exhibit potent antimicrobial spectrum against a variety of bacteria including Gram negative bacteria and/or Gram positive bacteria, corresponding pharmaceutical compositions, methods of making, treatment methods for bacterial infections or uses thereof.

  本发明涉及具有第3侧链上季铵基团的2-取代头孢菌素化合物（I）, 与儿茶酚基团一起更佳，或其药学上可接受的盐，对包括革兰氏阴性菌和/或革兰氏阳性菌在内的多种细菌具有强效的抗微生物谱，相应的制药组合物，制备方法，治疗细菌感染的方法或其用途。
• [EN] HETEROCYCLES AND USES THEREOF<br/>[FR] HÉTÉROCYCLES ET LEURS UTILISATIONS
  申请人：KUMQUAT BIOSCIENCES INC

  公开号：WO2022192598A1

  公开（公告）日：2022-09-15

  The present disclosure provides compounds and pharmaceutically acceptable salt thereof, and methods of using the same. The compounds and methods have a range of utilities as therapeutics, diagnostics, and research tools. In particular, the subject compositions and methods are useful for reducing signaling output of oncogenic proteins.

  本公开提供化合物及其药用可接受盐，并提供使用这些物质的方法。这些化合物和方法具有各种用途，可用作治疗剂、诊断剂和研究工具。特别地，本文所述的组合物和方法对于减少致癌蛋白的信号输出非常有用。
• 2 substituted cephem compounds
  申请人：Glaxo Group Limited

  公开号：US10174053B2

  公开（公告）日：2019-01-08

  The compounds of the subject invention are related to 2-substituted cephem compounds, which have a wide antimicrobial spectrum, in particular exhibit potent antimicrobial activity against beta-lactamase producing Gram negative bacteria, and pharmaceutical compositions comprising the same.

  本发明的化合物与 2-取代的头孢化合物有关，它们具有广泛的抗菌谱，特别是对β-内酰胺酶产生的革兰氏阴性菌具有强效抗菌活性，以及包含这些化合物的药物组合物。