5-methyl-2,5-diazatetracyclo[13.4.0.02,7.08,13]nonadeca-1(19),8,10,12,15,17-hexaene;N-methyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)propan-1-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: 5-methyl-2,5-diazatetracyclo[13.4.0.02,7.08,13]nonadeca-1(19),8,10,12,15,17-hexaene;N-methyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)propan-1-amine
• 化学式: C37H41N3
• 分子量: 527.7
• InChiKey: YWPWVTJOWDSHIB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.91
• 重原子数：
  40
• 可旋转键数：
  3
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  18.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Combination of adrenalin with an antidepressant for use in the treatment of shocks
  申请人：BIOPROJET

  公开号：US10952987B2

  公开（公告）日：2021-03-23

  The present invention concerns a novel combination of adrenalin with an antidepressant and its use as a pharmaceutical composition for the treatment of shocks. A method is also provided for treating a subject in need thereof by administering the combination of adrenaline with an antidepressant. The pharmaceutical composition is to be administered by injection.

  本发明涉及肾上腺素与抗抑郁药的新型组合及其作为药物组合物治疗休克的用途。本发明还提供了一种方法，通过施用肾上腺素与抗抑郁药的组合物来治疗有需要的受试者。该药物组合物通过注射给药。
• A COMBINATION OF ADRENALIN WITH AN ANTIDEPRESSANT FOR USE IN THE TREATMENT OF SHOCKS
  申请人：Bioprojet

  公开号：EP2903607A1

  公开（公告）日：2015-08-12
• EP2903607B1
  申请人：——

  公开号：EP2903607B1

  公开（公告）日：2017-08-16
• A Combination of Adrenaline with an Antidepressant for Use in the Treatment of Shocks
  申请人：BIOPROJET

  公开号：US20150306065A1

  公开（公告）日：2015-10-29

  The present invention concerns a novel combination of adrenalin with an antidepressant and its use as a pharmaceutical composition for the treatment of shocks. The pharmaceutical composition is to be administered by injection.
• COMBINATION OF ADRENALIN WITH AN ANTIDEPRESSANT FOR USE IN THE TREATMENT OF SHOCKS
  申请人：BIOPROJET

  公开号：US20190117614A1

  公开（公告）日：2019-04-25

  The present invention concerns a novel combination of adrenalin with an antidepressant and its use as a pharmaceutical composition for the treatment of shocks. A method is also provided for treating a subject in need thereof by administering the combination of adrenaline with an antidepressant. The pharmaceutical composition is to be administered by injection.