(4,5,6-Triphenylpyrimidin-2-yl)methylphosphanium;bromide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: (4,5,6-Triphenylpyrimidin-2-yl)methylphosphanium;bromide
• 英文别名: (4,5,6-triphenylpyrimidin-2-yl)methylphosphanium;bromide
• 化学式: C23H20BrN2P
• 分子量: 435.3
• InChiKey: SXYWOXQKVGZWAE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.59
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• CYCLIC DEPSIPEPTIDE COMPOUNDS AND THEIR USES
  申请人：Cypralis Limited

  公开号：US20150259386A1

  公开（公告）日：2015-09-17

  The present invention relates to novel cycloundecadepsipeptide compounds and their analogues which bind and inhibit cyclophilins, have reduced immunosuppressive activity and improved physicochemical properties including water solubility. The present invention further relates to pharmaceutical compositions containing said depsipeptide compounds and their analogues for use in the treatment or prevention of diseases and pathologies which may be ameliorated by the inhibition of cyclophilin activity.

  本发明涉及一种新型环十一肽类化合物及其类似物，其能够结合并抑制环孢菌素，具有降低的免疫抑制活性和改善的物理化学性质，包括水溶性。本发明还涉及包含所述depsipeptide化合物及其类似物的药物组合物，用于治疗或预防可能通过抑制环孢菌素活性而改善的疾病和病理状态。
• US9382295B2
  申请人：——

  公开号：US9382295B2

  公开（公告）日：2016-07-05
• US9895412B2
  申请人：——

  公开号：US9895412B2

  公开（公告）日：2018-02-20
• [EN] CYCLIC DEPSIPEPTIDE COMPOUNDS AND THEIR USES<br/>[FR] COMPOSÉS DÉPSIPEPTIDES CYCLIQUES ET LEURS UTILISATIONS
  申请人：CYPRALIS LTD

  公开号：WO2014053834A1

  公开（公告）日：2014-04-10

  The present invention relates to novel cycloundecadepsipeptide compounds and their analogues which bind and inhibit cyclophilins, have reduced immunosuppressive activity and improved physicochemical properties including water solubility.The present invention further relates to pharmaceutical compositions containing said depsipeptide compounds and their analogues for use in the treatment or prevention of diseases and pathologies which may be ameliorated by the inhibition ofcyclophilin activity.