2-(4-Bromophenyl)-3-methylpyridine | 885955-78-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-(4-Bromophenyl)-3-methylpyridine
• CAS: 885955-78-2
• 化学式: C₁₂H₁₀BrN
• 分子量: 248.122
• InChiKey: MFJDQHVWRUACHM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-(4-Bromophenyl)-3-methylpyridine 在 potassium permanganate 作用下， 以 水 为溶剂， 生成 7-bromo-4-azafluorenone
  参考文献：
  名称：

  인데노피리딘계 화합물 및 이를 포함한 유기 발광 소자

  摘要：

  嘌呤类化合物及其中包含的有机发光器件被揭示。

  公开号：

  KR20150026114A
• 作为产物：
  描述：

  2-溴-3-甲基吡啶 、 4-溴苯硼酸 在 四(三苯基膦)钯 、 sodium carbonate 作用下， 以 乙醇 、 水 、 甲苯 为溶剂， 反应 16.0h， 以54%的产率得到2-(4-Bromophenyl)-3-methylpyridine
  参考文献：
  名称：

  Ru(II)催化CH键活化原位生成3,3,3-三氟-1-丙炔：一种简便实用的β-三氟甲基苯乙烯制备方法

  摘要：

  开发了一种前所未有的 Ru 催化的C−H 键加氢芳基化反应，由廉价的 2-溴-3,3,3-三氟丙烯原位生成 3,3,3-三氟丙炔，以获取 β-三氟甲基苯乙烯。多种（杂）芳烃被官能化，选择性地产生E异构体。详细的机理研究和 DFT 计算支持不含芳烃的环金属化 Ru(II) 物质和双环金属化 Ru 络合物作为关键中间体的参与。

  DOI：

  10.1002/chem.202201928

文献信息

• Palladium-catalyzed ortho-acylation of 2-aryl pyridine derivatives using arylmethyl amines as new acyl sources
  作者：Qian Zhang、Fan Yang、Yangjie Wu

  DOI：10.1039/c3cc42106f

  日期：——

  A facile and efficient protocol for palladium-catalyzed ortho-acylation of 2-aryl pyridines was developed. Note that this acylation utilized arylmethyl amines as new, cheap and readily available acylation reagents and exhibited high regioselectivity for 2-aryl pyridines bearing a meta-substituent in the aryl ring moiety.

  开发了一种简便高效的钯催化邻位酰化2-芳基吡啶的协议。值得注意的是，该酰化反应采用了芳基甲基胺作为新的、廉价且易获得的酰化试剂，并对在芳环中具有间位取代基的2-芳基吡啶表现出高的区域选择性。
• Borane-Catalyzed Reduction of Pyridines via a Hydroboration/Hydrogenation Cascade
  作者：Zhao-Ying Yang、Heng Luo、Ming Zhang、Xiao-Chen Wang

  DOI：10.1021/acscatal.1c02876

  日期：2021.9.3

  of pyridines. The method was particularly effective for 2,3-disubstituted pyridines, which generated piperidines in high yields with high cis selectivity. Mechanistic studies indicated that the pyridine substrates and the piperidine products sequentially acted as bases in cooperation with B(C6F5)3 to split H2. The broad functional group tolerance of the method allowed its use for the synthesis of some

  我们已经开发了一种用于 B(C 6 F 5 ) 3催化的吡啶的硼氢化/氢化级联还原的方法。该方法对 2,3-二取代吡啶特别有效，它以高产率和高顺式选择性生成哌啶。机理研究表明，吡啶底物和哌啶产物依次作为碱基与B(C 6 F 5 ) 3合作分裂H 2。该方法的广泛官能团耐受性使其可用于合成一些生物活性分子。
• ANTHRACENE DERIVATIVE AND ORGANIC ELECTROLUMINESCENT ELEMENT USING THE SAME
  申请人：JNC CORPORATION

  公开号：US20150014671A1

  公开（公告）日：2015-01-15

  This organic electroluminescent element is manufactured by using an anthracene derivative having a pyridyl aryl group substituted with an alkyl represented by formula (1) as an electron transport material, and satisfies characteristics such as the following in an adequate and well-balanced manner: improves the external quantum efficiency of the light-emitting element, which is generally required by the electron transport material; reduces the drive voltage of the light-emitting element; and increases the life of the element. (In formula (1), Ar is a divalent or trivalent benzene or naphthalene; R is hydrogen or an alkyl with a carbon number of 1 to 6, but all of the Rs never simultaneously form hydrogen; and R 1 to R 4 are, individually, hydrogen, an alkyl with a carbon number of 1 to 6, a cycloalkyl with a carbon number of 3 to 6, or an aryl with a carbon number of 6 to 20.)

  这种有机电致发光元件是通过使用一个含有吡啶基芳基取代的烷基的蒽衍生物作为电子传输材料来制造的，它以适当且平衡的方式满足以下特性：提高通常由电子传输材料要求的发光元件的外部量子效率；降低发光元件的驱动电压；并延长元件的使用寿命。（在公式（1）中，Ar是二价或三价苯或萘；R是氢或碳数为1到6的烷基，但所有的R从不同时形成氢；R1到R4分别是氢，碳数为1到6的烷基，碳数为3到6的环烷基或碳数为6到20的芳基。）
• Palladium catalyzed ortho-C–H-benzoxylation of 2-arylpyridines using iodobenzene dibenzoates
  作者：Qian Zhang、Ying Wang、Tingting Yang、Li Li、Dong Li

  DOI：10.1016/j.tetlet.2015.09.097

  日期：2015.10

  A palladium-catalyzed ortho-C-H-benzoxylation of 2-arylpyridines using iodobenzene dibenzoates has been developed. The reaction employed the stable and easily accessible hypervalent iodine reagents as both benzoxylate source and oxidant which made the protocol simple and facile. It showed high regioselectivity and good functional group tolerance, and gave the mono-benzoxylation products in moderate to excellent yields. (C) 2015 Elsevier Ltd. All rights reserved.
• COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS
  申请人：Kozlowski Joseph A.

  公开号：US20120010181A1

  公开（公告）日：2012-01-12

  This invention relates to compounds of the Formula (I): (Chemical formula should be inserted here as it appears on abstract in paper form) (I) or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF—or combinations thereof.