6-[2-(2-Methylphenyl)pyrazol-3-yl]-1-phenylbenzimidazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 6-[2-(2-Methylphenyl)pyrazol-3-yl]-1-phenylbenzimidazole
• 英文别名: 6-[2-(2-methylphenyl)pyrazol-3-yl]-1-phenylbenzimidazole
• 化学式: C₂₃H₁₈N₄
• 分子量: 350.4
• InChiKey: GUGZQXPEGIRTAM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  35.6
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• BENZIMIDAZOLES AS CNS ACTIVE AGENTS
  申请人：F.Hoffmann-La Roche AG

  公开号：EP2903980A1

  公开（公告）日：2015-08-12
• [EN] BENZIMIDAZOL.ES AS CNS ACTIVE AGENTS<br/>[FR] BENZIMIDAZOLES EN TANT QU'AGENTS ACTIFS SUR LE SNC
  申请人：HOFFMANN LA ROCHE

  公开号：WO2014053409A1

  公开（公告）日：2014-04-10

  The present invention relates to compounds of general formula wherein R1 hydrogen, lower alkyl, halogen or lower alkyl substituted by halogen; R2 is hydrogen or halogen; X1 is N or CH; X2 is N or CH; with the proviso that only one of X1 or X2 is N; X3 is C(R) or N; and R is hydrogen, lower alkyl, halogen, lower alkyl substituted by halogen, lower alkoxy or SO2-lower alkyl; or to a pharmaceutically acceptable acid addition salt, to a racemic mixture or to its corresponding enantiomer and/or optical isomers thereof. The compounds may be used for the treatment of schizophrenia, obsessive-compulsive personality disorder, major depression, bipolar disorders, anxiety disorders, normal aging, epilepsy, retinal degeneration, traumatic brain injury, spinal cord injury, post-traumatic stress disorder, panic disorder, Parkinson's disease, dementia, Alzheimer's disease, mild cognitive impairment, chemotherapy-induced cognitive dysfunction, Down syndrome, autism spectrum disorders, hearing loss, tinnitus, spinocerebellar ataxia, amyotrophic lateral sclerosis, multiple sclerosis, Huntington's disease, stroke, radiation therapy, chronic stress, abuse of neuro-active drugs, such as alcohol, opiates, methamphetamine, phencyclidine and cocaine.