1-(4-Chlorophenyl)-6-[2-(4-fluorophenyl)pyrazol-3-yl]benzimidazole;6-[2-(4-fluorophenyl)pyrazol-3-yl]-1-[4-(trifluoromethyl)phenyl]benzimidazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 1-(4-Chlorophenyl)-6-[2-(4-fluorophenyl)pyrazol-3-yl]benzimidazole;6-[2-(4-fluorophenyl)pyrazol-3-yl]-1-[4-(trifluoromethyl)phenyl]benzimidazole
• 英文别名: 1-(4-chlorophenyl)-6-[2-(4-fluorophenyl)pyrazol-3-yl]benzimidazole;6-[2-(4-fluorophenyl)pyrazol-3-yl]-1-[4-(trifluoromethyl)phenyl]benzimidazole
• 化学式: C45H28ClF5N8
• 分子量: 811.2
• InChiKey: SCYYCLAVFLSFLQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.71
• 重原子数：
  59
• 可旋转键数：
  6
• 环数：
  10.0
• sp3杂化的碳原子比例：
  0.02
• 拓扑面积：
  71.3
• 氢给体数：
  0
• 氢受体数：
  9

文献信息

• BENZIMIDAZOLES AS CNS ACTIVE AGENTS
  申请人：F.Hoffmann-La Roche AG

  公开号：EP2903980A1

  公开（公告）日：2015-08-12
• [EN] BENZIMIDAZOL.ES AS CNS ACTIVE AGENTS<br/>[FR] BENZIMIDAZOLES EN TANT QU'AGENTS ACTIFS SUR LE SNC
  申请人：HOFFMANN LA ROCHE

  公开号：WO2014053409A1

  公开（公告）日：2014-04-10

  The present invention relates to compounds of general formula wherein R1 hydrogen, lower alkyl, halogen or lower alkyl substituted by halogen; R2 is hydrogen or halogen; X1 is N or CH; X2 is N or CH; with the proviso that only one of X1 or X2 is N; X3 is C(R) or N; and R is hydrogen, lower alkyl, halogen, lower alkyl substituted by halogen, lower alkoxy or SO2-lower alkyl; or to a pharmaceutically acceptable acid addition salt, to a racemic mixture or to its corresponding enantiomer and/or optical isomers thereof. The compounds may be used for the treatment of schizophrenia, obsessive-compulsive personality disorder, major depression, bipolar disorders, anxiety disorders, normal aging, epilepsy, retinal degeneration, traumatic brain injury, spinal cord injury, post-traumatic stress disorder, panic disorder, Parkinson's disease, dementia, Alzheimer's disease, mild cognitive impairment, chemotherapy-induced cognitive dysfunction, Down syndrome, autism spectrum disorders, hearing loss, tinnitus, spinocerebellar ataxia, amyotrophic lateral sclerosis, multiple sclerosis, Huntington's disease, stroke, radiation therapy, chronic stress, abuse of neuro-active drugs, such as alcohol, opiates, methamphetamine, phencyclidine and cocaine.