(Z)-2-(1-methylbenzimidazol-2-yl)-3-pyridin-4-ylprop-2-enenitrile

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: (Z)-2-(1-methylbenzimidazol-2-yl)-3-pyridin-4-ylprop-2-enenitrile
• 化学式: C₁₆H₁₂N₄
• 分子量: 260.29
• InChiKey: UWXRQZSSEWNKIX-RAXLEYEMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  54.5
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Identification of Small Molecule Inhibitors of Jumonji AT-Rich Interactive Domain 1A (JARID1A) and 1B (JARID1B) Histone Demethylase
  申请人：Yale University

  公开号：US20150272939A1

  公开（公告）日：2015-10-01

  The present invention includes a novel high-throughput screen capable of identifying compounds that inhibit JARID1B demethylase activity or JARID1A demethylase activity. The present invention further includes novel inhibitors of JARID1B demethylase activity and/or JARID1A demethylase activity, and methods using the same.
• [EN] IDENTIFICATION OF SMALL MOLECULE INHIBITORS OF JUMONJI AT-RICH INTERACTIVE DOMAIN 1A (JARID1A) AND 1B (JARID1B) HISTONE DEMETHYLASE<br/>[FR] IDENTIFICATION DE PETITES MOLÉCULES INHIBITRICES D'HISTONE DÉMÉTHYLASE À DE DOMAINE JUMONJI 1A (JARID1A) ET 1B (JARID1B) INTERACTIF RICHE EN AT,
  申请人：UNIV YALE

  公开号：WO2014055634A1

  公开（公告）日：2014-04-10

  The present invention includes a novel high-throughput screen capable of identifying compounds that inhibit JARID1B demethylase activity or JARID1A demethylase activity. The present invention further includes novel inhibitors of JARID1B demethylase activity and/or JARID1A demethylase activity, and methods using the same.