trans-1,2-bis-((diphenylphosphino)methyl)cyclobutane

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: trans-1,2-bis-((diphenylphosphino)methyl)cyclobutane
• 英文别名: trans-1,2-bis(diphenylphosphinomethyl)cyclobutene；trans-1,2-Bis(diphenylphosphinomethyl)cyclobutane；[(1R,2R)-2-(diphenylphosphanylmethyl)cyclobutyl]methyl-diphenylphosphane
• 化学式: C₃₀H₃₀P₂
• 分子量: 452.516
• InChiKey: KMTTUERWIBEAEN-UIOOFZCWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  32
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  [(norbornadiene)rhodium(I)chloride]2 、 trans-1,2-bis-((diphenylphosphino)methyl)cyclobutane 在 NaClO₄ 作用下， 以 not given 为溶剂， 生成 (bicyclo(2.2.1)heptadiene)((1R,2R)-trans-1,2-bis((diphenylphosphino)methyl)cyclobutane)rhodium(I) perchlorate
  参考文献：
  名称：

  Townsend, John M.; Blount, John F., Inorganic Chemistry, 1981, vol. 20, # 1, p. 269 - 271

  摘要：

  DOI：

文献信息

• Method Of Reducing A Functional Group In An Oxidized Form
  申请人：Mignani Gerard

  公开号：US20080214857A1

  公开（公告）日：2008-09-04

  A novel method of reducing a functional group in an oxidised form. The invention relates more particularly to the reduction of aldehyde, ketone, ester, lactone, nitrile or phosphine oxide groups. The reduction method according to the invention is characterised in that it comprises exposing the substrate including the functional group to be reduced to the presence of a siloxane-type compound of the following formula (I), combined with a Lewis acid-type catalyst. In said formula (I):—R1 and R2, which are the same or different, are an alkyl, cycloalkyle or aryl group, —X is a digit from 0 to 50.

  一种在氧化形式中减少官能团的新方法。该发明更特别地涉及醛、酮、酯、内酯、腈或膦氧化物基团的还原。根据该发明的还原方法的特征在于，它包括将包括待还原的官能团的底物暴露于具有以下式（I）的硅氧烷类化合物和一种Lewis酸型催化剂的存在下。在所述式（I）中：—R1和R2，它们相同或不同，是烷基、环烷基或芳基，—X是从0到50的数字。
• Process for Producing Aliskiren
  申请人：Taddei Maurizio

  公开号：US20130071899A1

  公开（公告）日：2013-03-21

  A new route of synthesis of the compound Aliskiren of formula (I), used in the treatment of hypertension, is described.

  描述了一种用于治疗高血压的化合物阿利司钠（分子式为（I））的新合成途径。
• [EN] HYDROFORMYLATION PROCESS<br/>[FR] PROCÉDÉ D'HYDROFORMYLATION
  申请人：LYONDELL CHEMICAL TECH LP

  公开号：WO2010132087A1

  公开（公告）日：2010-11-18

  A process for the production of 4-hydroxybutyraldehyde is described. The process comprises reacting allyl alcohol with a mixture of carbon monoxide and hydrogen in the presence of a solvent and a catalyst comprising a rhodium complex and a diphosphine. The diphoshine is a trans-1,2-bis(bis(3,4-di-n-alkylphenyl)phosphinomethyl)cyclobutane and/or a 2,3-O-isopropylidene-2,3-dihydroxy-1,4-bis[bis(3,4-di-n-alkylphenyl)phosphino] butane. The process gives high yield of 4-hydroxybutyraldehyde compared to 3-hydroxy-2-methylpropionaldehyde.

  本发明涉及一种生产4-羟基丁醛的方法。该方法包括在溶剂和催化剂的存在下，将丙烯醇与一种一氧化碳和氢气的混合物反应，所述催化剂包括一个铑配合物和一个二膦。所述二膦是一种trans-1,2-双[双(3,4-二-n-烷基苯基)膦甲基]环丁烷和/或2,3-O-异丙亚甲基-2,3-双羟基-1,4-双[双(3,4-二-n-烷基苯基)膦基]丁烷。与3-羟基-2-甲基丙醛相比，该方法可高产4-羟基丁醛。
• Hydroformylation of olefinic compounds
  申请人：Kuraray Co., Ltd.

  公开号：US04306087A1

  公开（公告）日：1981-12-15

  In hydroformylating an olefinic compound in an organic solvent and in the presence of a rhodium complex and a trisubstituted phosphine to give the corresponding aldehyde, at least one diphosphino compound of the following general formula (I) is added to the reaction system in a proportion of 0.20 to 5.0 equivalents per rhodium atom in the rhodium complex ##STR1## wherein A.sup.1 and A.sup.2, respectively, are aryl groups; R.sup.1 and R.sup.2, respectively, are an aryl group or a saturated hydrocarbon residue containing 1 or more carbon atoms; and ##STR2## represents a substituted or unsubstituted alicyclic hydrocarbon group containing 3 to 6 carbon atoms in the main ring. The addition of diphosphino compound (I) has a remarkable life-prolonging effect on the rhodium catalyst.

  在有机溶剂中，在铑配合物和三取代膦的存在下，通过水合甲酰化反应将烯烃化合物转化为相应的醛。在反应体系中加入以下通式（I）的至少一种双膦化合物，每个铑原子的比例为0.20至5.0当量：##STR1## 其中，A1和A2分别是芳基；R1和R2分别是含有1个或多个碳原子的芳基或饱和碳氢残基；而##STR2##表示含有3至6个碳原子的取代或未取代的脂环烃基。加入双膦化合物（I）对铑催化剂具有显著的延长寿命的作用。
• High linear selectivity ligand for allyl alcohol hydroformylation
  申请人：Lyondell Chemical Technology, L.P.

  公开号：US10807934B1

  公开（公告）日：2020-10-20

  A process for selectively producing 4-hydroxybutyraldehyde from allyl alcohol is described. The process comprises reacting allyl alcohol with a mixture of carbon monoxide and hydrogen in the presence of a solvent and a catalyst system comprising a rhodium complex and a trans-1,2-bis(bis(3,4,5-tri-n-alkylphenyl)phosphinomethyl)-cyclobutane. The process gives high yield of 4-hydroxybutyraldehyde compared to temperature.

  本发明描述了一种从丙烯醇选择性地生产4-羟基丁醛的过程。该过程包括在溶剂和催化剂体系的存在下，将丙烯醇与一种混合物（包括一氧化碳和氢气）反应，所述催化剂体系包括一个铑配合物和一个trans-1,2-双（双（3,4,5-三-n-烷基苯基）磷酰甲基）环丁烷。与温度相比，该过程可以高产得4-羟基丁醛。