N4-Acetylcytidine triphosphate

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷酸
• 英文名称: N4-Acetylcytidine triphosphate
• 英文别名: [[(2R,3S,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
• 化学式: C₁₁H₁₈N₃O₁₅P₃
• 分子量: 525.19
• InChiKey: PMLKMGFNRKVFTQ-PEBGCTIMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.2
• 重原子数：
  32
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  271
• 氢给体数：
  7
• 氢受体数：
  15

文献信息

• Methods and products for nucleic acid production and delivery
  申请人：Factor Bioscience Inc.

  公开号：US10124042B2

  公开（公告）日：2018-11-13

  The present invention relates in part to nucleic acids, including nucleic acids encoding proteins, therapeutics and cosmetics comprising nucleic acids, methods for delivering nucleic acids to cells, tissues, organs, and patients, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, therapeutics, and cosmetics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules, including cells present in vivo. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.

  本发明部分涉及核酸，包括编码蛋白质的核酸，包含核酸的治疗剂和化妆品，向细胞、组织、器官和患者提供核酸的方法，使用核酸诱导细胞表达蛋白质的方法，用于转染、基因编辑和重编程细胞的方法、试剂盒和装置，以及使用这些方法、试剂盒和装置生产的细胞、生物体、治疗剂和化妆品。本文描述了改变细胞 DNA 序列的方法和产品，以及使用合成 RNA 分子诱导细胞（包括体内细胞）表达蛋白质的方法和产品。此外，还介绍了包含编码基因编辑蛋白的核酸的治疗方法。
• Nucleic acid products and methods of administration thereof
  申请人：Factor Bioscience Inc.

  公开号：US10137206B2

  公开（公告）日：2018-11-27

  The present invention relates in part to nucleic acids, including nucleic acids encoding proteins, therapeutics and cosmetics comprising nucleic acids, methods for delivering nucleic acids to cells, tissues, organs, and patients, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, therapeutics, and cosmetics produced using these methods, kits, and devices.

  本发明部分涉及核酸，包括编码蛋白质的核酸，包含核酸的治疗剂和化妆品，向细胞、组织、器官和患者输送核酸的方法，使用核酸诱导细胞表达蛋白质的方法，用于转染、基因编辑和重编程细胞的方法、试剂盒和装置，以及使用这些方法、试剂盒和装置生产的细胞、生物体、治疗剂和化妆品。
• Methods and products for expressing proteins in cells
  申请人：Factor Bioscience Inc.

  公开号：US10415060B2

  公开（公告）日：2019-09-17

  The present invention relates in part to nucleic acids encoding proteins, therapeutics comprising nucleic acids encoding proteins, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.

  本发明部分涉及编码蛋白质的核酸，包含编码蛋白质的核酸的治疗剂，使用核酸诱导细胞表达蛋白质的方法，用于转染、基因编辑和重编程细胞的方法、试剂盒和装置，以及使用这些方法、试剂盒和装置生产的细胞、生物体和治疗剂。本文介绍了改变细胞 DNA 序列的方法和产品，以及使用合成 RNA 分子诱导细胞表达蛋白质的方法和产品。此外，还介绍了包含编码基因编辑蛋白的核酸的治疗方法。
• METHODS AND PRODUCTS FOR EXPRESSING PROTEINS IN CELLS
  申请人：Factor Bioscience Inc.

  公开号：EP2914728A1

  公开（公告）日：2015-09-09
• METHODS AND PRODUCTS FOR NUCLEIC ACID PRODUCTION AND DELIVERY
  申请人：Factor Bioscience Inc.

  公开号：EP3099801A1

  公开（公告）日：2016-12-07