6-Methyl-4-oxaspiro[2.4]heptane

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧唑烯
• 英文名称: 6-Methyl-4-oxaspiro[2.4]heptane
• 英文别名: 6-methyl-4-oxaspiro[2.4]heptane
• 化学式: C₇H₁₂O
• 分子量: 112.17
• InChiKey: BGRNLZJZEUFWIV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• C-GLYCOSIDE DERIVATIVES
  申请人：Xuanzhu Pharma Co., Ltd.

  公开号：EP2725031A1

  公开（公告）日：2014-04-30

  The present invention involves a compound represented by general formula (I), a derivative thereof and a use thereof: wherein R1, R2, R3, R4, R5a, R5b, R5c and X are defined as in the description.

  本发明涉及通式 (I) 所代表的化合物、其衍生物及其用途： 其中 R1、R2、R3、R4、R5a、R5b、R5c 和 X 的定义如说明书所述。
• AMINO PYRANOID RING DERIVATIVE AND COMPOSITION AND USE THEREOF
  申请人：Sichuan Haisco Pharmaceutical Co., Ltd.

  公开号：EP3159344A1

  公开（公告）日：2017-04-26

  The present invention relates to an amino pyran ring derivative and a composition and use thereof, and in particular, to an amino pyran ring derivative represented by general formula (I) or a stereoisomer, a pharmaceutically acceptable salt or a prodrug thereof, a pharmaceutical composition comprising the derivative, and their medical use in the manufacture of a di-peptidyl peptidase IV (DPP-IV) inhibitor, in formula (I) the substituents are defined the same as those in the specification.

  本发明涉及一种氨基吡喃环衍生物及其组合物和用途，特别是通式（I）代表的氨基吡喃环衍生物或其立体异构体、其药学上可接受的盐或原药、包含该衍生物的药物组合物，以及它们在制造二肽基肽酶 IV（DPP-IV）抑制剂中的医疗用途、 在式 (I) 中，取代基的定义与说明书中的相同。
• [EN] RET INHIBITOR, PHARMACEUTICAL COMPOSITION AND USE THEREOF<br/>[FR] INHIBITEUR DE RET, COMPOSITION PHARMACEUTIQUE ET UTILISATION ASSOCIÉE<br/>[ZH] 一种RET抑制剂、其药物组合物及其用途
  申请人：SUNSHINE LAKE PHARMA CO LTD

  公开号：WO2021043209A1

  公开（公告）日：2021-03-11

  涉及一种药物领域中RET抑制剂、其药物组合物及其用途。具体地，涉及一种式(I)所示的化合物，或式(I)所示化合物的立体异构体、几何异构体、互变异构体、氮氧化物、溶剂化物、代谢产物、药学上可接受的盐或前药，还涉及包含所述这些化合物的药物组合物、以及所述这些化合物及其药物组合物在制备药物中的用途，该药物尤其用于治疗和预防可用RET相关的疾病和病症，包括癌症、肠易激综合征和/或与肠易激综合征相关的疼痛。
• C-GLYCOSIDE DERIVATIVE
  申请人：XUANZHU PHARMA CO., LTD.

  公开号：US20170101388A1

  公开（公告）日：2017-04-13

  The present invention involves a compound represented by general formula (I), a derivative thereof and a use thereof: wherein R 1 , R 2 , R 3 , R 4 , R 5a , R 5b , R 5c and X are defined as in the description.
• AMINO PRYAN RING DERIVATIVE AND COMPOSITION AND USE THEREOF
  申请人：Sichuan Haisco Pharmaceutical Co., Ltd.

  公开号：US20170121338A1

  公开（公告）日：2017-05-04

  The present disclosure relates to an amino pyran ring derivative and a composition and use thereof, and in particular, to an amino pyran ring derivative represented by general formula (I) or a stereoisomer, a pharmaceutically acceptable salt or a prodrug thereof, a pharmaceutical composition comprising the derivative, and their medical use in the manufacture of a di-peptidyl peptidase IV (DPP-IV) inhibitor, in formula (I) the substituents are defined the same as those in the specification.