(2,5-Dioxopyrrolidin-1-yl) 2-(2,3-dipropoxypropoxy)acetate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: (2,5-Dioxopyrrolidin-1-yl) 2-(2,3-dipropoxypropoxy)acetate
• 英文别名: (2,5-dioxopyrrolidin-1-yl) 2-(2,3-dipropoxypropoxy)acetate
• 化学式: C₁₅H₂₅NO₇
• 分子量: 331.36
• InChiKey: ZJWPJODVKYIUGC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  23
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  91.4
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• NUCLEOPHILIC CATALYSTS FOR OXIME LINKAGE
  申请人：BAXTER HEALTHCARE SA

  公开号：US20140121351A1

  公开（公告）日：2014-05-01

  The invention relates to materials and methods of conjugating a water soluble polymer to an oxidized carbohydrate moiety of a therapeutic protein comprising contacting the oxidized carbohydrate moiety with an activated water soluble polymer under conditions that allow conjugation. More specifically, the present invention relates to the aforementioned materials and methods wherein the water soluble polymer contains an active aminooxy group and wherein an oxime or hydrazone linkage is formed between the oxidized carbohydrate moiety and the active aminooxy group on the water soluble polymer, and wherein the conjugation is carried out in the presence of a nucleophilic catalyst.