rac-6-chloro-8-[(2,6-difluorobenzyl)oxy]-2-methyl-N-(piperidin-2-ylmethyl)imidazo[1,2-a]pyridine-3-carboxamide | 1609341-28-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: rac-6-chloro-8-[(2,6-difluorobenzyl)oxy]-2-methyl-N-(piperidin-2-ylmethyl)imidazo[1,2-a]pyridine-3-carboxamide
• 英文别名: 6-chloro-8-[(2,6-difluorophenyl)methoxy]-2-methyl-N-(piperidin-2-ylmethyl)imidazo[1,2-a]pyridine-3-carboxamide
• CAS: 1609341-28-7
• 化学式: C₂₂H₂₃ClF₂N₄O₂
• 分子量: 448.9
• InChiKey: FGIILAXKRANLGX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  67.7
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  rac-6-chloro-8-[(2,6-difluorobenzyl)oxy]-2-methyl-N-(piperidin-2-ylmethyl)imidazo[1,2-a]pyridine-3-carboxamide 在 Daicel Chiralpak OZ-H 作用下， 以 2-甲基戊烷 、 二乙胺 、 异丙醇 为溶剂， 生成 6-chloro-8-[(2,6-difluorobenzyl)oxy]-2-methyl-N-(piperidin-2-ylmethyl)imidazo[1,2-a]pyridine-3-carboxamide 、 6-chloro-8-[(2,6-difluorobenzyl)oxy]-2-methyl-N-(piperidin-2-ylmethyl)imidazo[1,2-a]pyridine-3-carboxamide
  参考文献：
  名称：

  Amino-substituted imidazo[1,2-a]pyridinecarboxamides and their use

  摘要：

  本申请涉及新型取代咪唑[1,2-a]吡啶-3-羧酰胺，其制备方法，单独或组合使用以治疗和/或预防疾病，以及用于制备治疗和/或预防疾病的药物，特别是用于治疗和/或预防心血管疾病。

  公开号：

  US20140128372A1

文献信息

• AMINO-SUBSTITUTED IMIDAZO[1,2-A]PYRIDINECARBOXAMIDES AND THEIR USE
  申请人：BAYER PHARMA AKTIENGESELLSCHAFT

  公开号：US20150274719A1

  公开（公告）日：2015-10-01

  The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.

  本申请涉及新型取代的咪唑并[1,2-a]吡啶-3-羧酰胺，其制备方法，其单独或与其他药物联合用于治疗和/或预防疾病，以及其用于制备治疗和/或预防疾病的药物，特别是用于治疗和/或预防心血管疾病。
• Amino-substituted imidazo[1,2-A] pyridinecarboxamides and their use
  申请人：BAYER PHARMA AKTIENGESELLSCHAFT

  公开号：US10662185B2

  公开（公告）日：2020-05-26

  The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides of the general formula (I) to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.

  本申请涉及通式 (I) 的新型取代咪唑并[1,2-a]吡啶-3-甲酰胺 它们的制备工艺，它们在治疗和/或预防疾病方面的单独用途或组合用途，以及它们在制备治疗和/或预防疾病（尤其是治疗和/或预防心血管疾病）的药物方面的用途。
• AMINO-SUBSTITUIERTE IMIDAZO[1,2-A]PYRIDINCARBOXAMIDE UND IHRE VERWENDUNG
  申请人：Bayer Pharma Aktiengesellschaft

  公开号：EP2914594B1

  公开（公告）日：2017-05-03
• AMINO-SUBSTITUTED IMIDAZO[1,2-A] PYRIDINECARBOXAMIDES AND THEIR USE
  申请人：BAYER PHARMA AKTIENGESELLSCHAFT

  公开号：US20190248783A9

  公开（公告）日：2019-08-15

  The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
• US9126998B2
  申请人：——

  公开号：US9126998B2

  公开（公告）日：2015-09-08