2-(3-chloropyridin-2-yl)-N-[2,4-dichloro-6-(methylcarbamoyl)phenyl]-5-fluoropyrazole-3-carboxamide | 500011-09-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(3-chloropyridin-2-yl)-N-[2,4-dichloro-6-(methylcarbamoyl)phenyl]-5-fluoropyrazole-3-carboxamide
• CAS: 500011-09-6
• 化学式: C₁₇H₁₁Cl₃FN₅O₂
• 分子量: 442.664
• InChiKey: RJYNUYVYDQFVAH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  88.9
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-[1-(3-chloro-2-pyridinyl)-3-fluoro-1H-pyrazol-5-yl]-6,8-dichloro-4H-3,1-benzoxazin-4-one 、 甲胺 以 四氢呋喃 为溶剂， 反应 0.25h， 以76%的产率得到2-(3-chloropyridin-2-yl)-N-[2,4-dichloro-6-(methylcarbamoyl)phenyl]-5-fluoropyrazole-3-carboxamide
  参考文献：
  名称：

  Synthesis of insecticidal fluorinated anthranilic diamides

  摘要：

  A series of highly active fluorinated anthranilic diamide insecticides have been prepared and their biological activity assessed on two aphid species in the search for systemically active compounds that control Hemiptera. In addition, we have demonstrated a new synthesis of N-aryl 3-fluoropyrazoles. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.12.017

文献信息

• Synthesis of insecticidal fluorinated anthranilic diamides
  作者：David A. Clark、George P. Lahm、Ben K. Smith、James D. Barry、Don G. Clagg

  DOI：10.1016/j.bmc.2007.12.017

  日期：2008.3.15

  A series of highly active fluorinated anthranilic diamide insecticides have been prepared and their biological activity assessed on two aphid species in the search for systemically active compounds that control Hemiptera. In addition, we have demonstrated a new synthesis of N-aryl 3-fluoropyrazoles. (C) 2007 Elsevier Ltd. All rights reserved.