2,3-Diacetyloxypropyl 2-(2,3-dihydroxypropoxy)acetate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: 2,3-Diacetyloxypropyl 2-(2,3-dihydroxypropoxy)acetate
• 英文别名: 2,3-diacetyloxypropyl 2-(2,3-dihydroxypropoxy)acetate
• 化学式: C₁₂H₂₀O₉
• 分子量: 308.28
• InChiKey: VZBMNPFBHYXMOW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  21
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  129
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• NOVEL LIPIDOMIMETIC COMPOUNDS AND USES THEREOF
  申请人：Gruell Holger

  公开号：US20140127135A1

  公开（公告）日：2014-05-08

  Disclosed are lipidomimetic compounds of formula I (I) wherein: G represents a group satisfying formula II: HO—CH 2 —CH(OH)—CH 2 -0} m -CH 2 —C(=0)-0-CH 2 }) q — formula II each n independently is an integer from 1-30; m is an integer from 1-10; q is 0 or 1. These compounds can be added to the lipid bilayer of thermosensitive liposomes, for the purpose of aiding in the prevention of leakage of the liposomes' contents at 37° C., and retarding clearance from circulation.
• US9061062B2
  申请人：——

  公开号：US9061062B2

  公开（公告）日：2015-06-23