2-[[8-Hydroxy-3,6-bis[5-(2-methylprop-2-enoylamino)pentoxysulfinylamino]pyren-1-yl]sulfonylamino]-6-(2-methylprop-2-enoylamino)hexanoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 芘
• 英文名称: 2-[[8-Hydroxy-3,6-bis[5-(2-methylprop-2-enoylamino)pentoxysulfinylamino]pyren-1-yl]sulfonylamino]-6-(2-methylprop-2-enoylamino)hexanoic acid
• 英文别名: 2-[[8-hydroxy-3,6-bis[5-(2-methylprop-2-enoylamino)pentoxysulfinylamino]pyren-1-yl]sulfonylamino]-6-(2-methylprop-2-enoylamino)hexanoic acid
• 化学式: C₄₄H₅₈N₆O₁₂S₃
• 分子量: 959.2
• InChiKey: HOUREBZSZNTUGF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  65
• 可旋转键数：
  30
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  315
• 氢给体数：
  8
• 氢受体数：
  17

文献信息

• Mobility-Modified Nucleobase Polymers and Methods of Using Same
  申请人：WOO Sam L.

  公开号：US20110160082A1

  公开（公告）日：2011-06-30

  The present invention relates generally to nucleobase polymer functionalizing reagents, to mobility-modified sequence-specific nucleobase polymers, to compositions comprising a plurality of mobility-modified sequence-specific nucleobase polymers, and to the use of such polymers and compositions in a variety of assays, such as, for example, for the detection of a plurality of selected nucleotide sequences within one or more target nucleic acids. The mobility-modifying polymers of the present invention include phosphoramidite reagents which can be joined to other mobility-modifying monomers and to sequence-specific oligonucleobase polymers via uncharged phosphate triester linkages. Addition of the mobility-modifying phosphoramidite reagents of the present invention to oligonucleobase polymers results in unexpectedly large effects the mobility of those modified oligonucleobase polymers, especially upon capillary electrophoresis in non-sieving media.

  本发明涉及核碱基聚合物功能化试剂，移动性修饰的序列特异性核碱基聚合物，包含多个移动性修饰的序列特异性核碱基聚合物的组合物，以及在各种测定中使用这些聚合物和组合物，例如，用于检测一个或多个目标核酸中的多个选择性核苷酸序列。本发明的移动性修饰聚合物包括磷酰胺试剂，可通过无电荷磷酸三酯键连接到其他移动性修饰单体和序列特异性寡核苷酸聚合物。将本发明的移动性修饰磷酰胺试剂添加到寡核苷酸聚合物中，会导致这些修饰的寡核苷酸聚合物的迁移率出现意外的大效应，特别是在非筛选介质的毛细管电泳中。
• DRY INSERTION AND ONE-POINT IN VIVO CALIBRATION OF AN OPTICAL ANALYTE SENSOR
  申请人：Glumetrics, Inc.

  公开号：US20140128694A1

  公开（公告）日：2014-05-08

  Disclosed are embodiments that relate to the deployment of a glucose sensor comprising an optical fiber into a physiological fluid, wherein the optical fiber has disposed along a distal region thereof a chemical indicator system comprising a fluorophore and a glucose binding moiety immobilized within a hydrogel, wherein the components of the chemical indicator system are in a dry state before deployment. Also disclosed is a one-point in vivo calibration of the chemical indicator system based on an independently measured glucose concentration.
• US9757057B2
  申请人：——

  公开号：US9757057B2

  公开（公告）日：2017-09-12