1-(2-bromo-1,1-dimethoxyethyl)-2-chlorobenzene | 1206904-28-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(2-bromo-1,1-dimethoxyethyl)-2-chlorobenzene
• CAS: 1206904-28-0
• 化学式: C₁₀H₁₂BrClO₂
• 分子量: 279.561
• InChiKey: VOYBCAHHJLQYPF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  甲醇 、 2-氯苯甲醛 在 哌啶 、 1,3-二溴-5,5-二甲基海因 作用下， 反应 12.0h， 以79%的产率得到1-(2-bromo-1,1-dimethoxyethyl)-2-chlorobenzene
  参考文献：
  名称：

  One-Step Conversion of Acetophenones to α-Haloacetophenone Dimethyl Acetals Using DCDMH/DBDMH and Molecular Sieve in Methanol

  摘要：

  Using DCDMH/DBDMH as N-halo reagent, piperidine as catalyst, and 4-A molecular sieve as water-removing agent, alpha-haloacetophenone dimethyl acetals were directly obtained from the solvent of methanol. As to the substrates with electron-withdrawing groups, the conversions were 80-100%.

  DOI：

  10.1080/00397911.2010.540696

文献信息

• [EN] NOVEL FUNCTIONALIZED 5-(PHENOXYMETHYL)-1,3-DIOXANE ANALOGS EXHIBITNG CYTOCHROME P450 INHIBITION<br/>[FR] NOUVEAUX ANALOGUES DE 5-(PHÉNOXYMÉTHYL)-1,3-DIOXANE FONCTIONNALISÉS PRÉSENTANT UNE ACTION INHIBITRICE DU CYTOCHROME P450
  申请人：CORTENDO AB PUBL

  公开号：WO2015048311A1

  公开（公告）日：2015-04-02

  Pharmaceutical compositions described in this document comprise 5-(phenoxymethyl)-1,3-dioxane analogs having a disease-modifying action in the treatment of diseases associated with the production of cortisol that include metabolic syndrome, obesity, headache, depression, hypertension, diabetes mellitus, Cushing's Syndrome, pseudo-Cushing syndrome, cognitive impairment, dementia, heart failure, renal failure, psoriasis, glaucoma, cardiovascular disease, cancer, stroke, incidentalomas, or any diseases involving the overproduction of cortisol.

  本文描述的药物组合物包括具有疾病修饰作用的5-(苯氧甲基)-1,3-二噁烷类似物，在治疗与皮质醇产生相关的疾病中发挥作用，包括代谢综合征、肥胖、头痛、抑郁症、高血压、糖尿病、库欣综合症、假性庫欣綜合症、认知障碍、痴呆、心力衰竭、肾衰竭、牛皮癣、青光眼、心血管疾病、癌症、中风、偶发性腺瘤或任何涉及皮质醇过度产生的疾病。
• NOVEL FUNCTIONALIZED 5-(PHENOXYMETHYL)-1,3-DIOXANE ANALOGS EXHIBITING CYTOCHROME P450 INHIBITION AND THEIR METHOD OF USE
  申请人：CORTENDO AB (PUBL)

  公开号：US20160244436A1

  公开（公告）日：2016-08-25

  Pharmaceutical compositions described in this document comprise 5-(phenoxymethyl)-1,3-dioxane analogs having a disease-modifying action in the treatment of diseases associated with the production of cortisol that include metabolic syndrome, obesity, headache, depression, hypertension, diabetes mellitus, Cushing's Syndrome, pseudo-Cushing syndrome, cognitive impairment, dementia, heart failure, renal failure, psoriasis, glaucoma, cardiovascular disease, cancer, stroke, incidentalomas, or any diseases involving the overproduction of cortisol.

  本文中描述的制药组合物包括具有疾病修饰作用的5-(苯氧甲基)-1,3-二噁烷类似物，用于治疗与皮质醇产生有关的疾病，包括代谢综合征、肥胖症、头痛、抑郁症、高血压、糖尿病、库欣综合征、假性库欣综合征、认知障碍、痴呆、心力衰竭、肾衰竭、牛皮癣、青光眼、心血管疾病、癌症、中风、偶发瘤或任何涉及皮质醇过度产生的疾病。