4-(2-bromo-1,1-dimethoxyethyl)-1,2-dichlorobenzene | 1206904-29-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(2-bromo-1,1-dimethoxyethyl)-1,2-dichlorobenzene
• CAS: 1206904-29-1
• 化学式: C₁₀H₁₁BrCl₂O₂
• 分子量: 314.006
• InChiKey: JWWODEODVLWOKN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  甲醇 、 3,4-二氯苯甲醛 在 哌啶 、 1,3-二溴-5,5-二甲基海因 作用下， 反应 12.0h， 以84%的产率得到4-(2-bromo-1,1-dimethoxyethyl)-1,2-dichlorobenzene
  参考文献：
  名称：

  One-Step Conversion of Acetophenones to α-Haloacetophenone Dimethyl Acetals Using DCDMH/DBDMH and Molecular Sieve in Methanol

  摘要：

  Using DCDMH/DBDMH as N-halo reagent, piperidine as catalyst, and 4-A molecular sieve as water-removing agent, alpha-haloacetophenone dimethyl acetals were directly obtained from the solvent of methanol. As to the substrates with electron-withdrawing groups, the conversions were 80-100%.

  DOI：

  10.1080/00397911.2010.540696

文献信息

• One-Step Conversion of Acetophenones to <font>α</font>-Haloacetophenone Dimethyl Acetals Using DCDMH/DBDMH and Molecular Sieve in Methanol
  作者：Bin Zhou、Zizhan Chen、Zubiao Zheng、Bingbing Han、Xinzhuo Zou

  DOI：10.1080/00397911.2010.540696

  日期：2012.5.15

  Using DCDMH/DBDMH as N-halo reagent, piperidine as catalyst, and 4-A molecular sieve as water-removing agent, alpha-haloacetophenone dimethyl acetals were directly obtained from the solvent of methanol. As to the substrates with electron-withdrawing groups, the conversions were 80-100%.