5-(N-4-chlorophenyl-N-isobutylcarbamoyl)-2-(4-(5,6-dichloro-1H-benzo[d]-imidazol-2-yI)benzamido)-benzoic acid | 1374776-10-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 5-(N-4-chlorophenyl-N-isobutylcarbamoyl)-2-(4-(5,6-dichloro-1H-benzo[d]-imidazol-2-yI)benzamido)-benzoic acid
• 英文别名: 5-[(4-chlorophenyl)-(2-methylpropyl)carbamoyl]-2-[[4-(5,6-dichloro-1H-benzimidazol-2-yl)benzoyl]amino]benzoic acid
• CAS: 1374776-10-9
• 化学式: C₃₂H₂₅Cl₃N₄O₄
• 分子量: 635.934
• InChiKey: PNJLKAMVABNGGQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.3
• 重原子数：
  43
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  115
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• BIOMARKERS FOR THE DIAGNOSIS OF INTERSTITIAL CYSTITIS
  申请人：WILLIAM BEAUMONT HOSPITAL

  公开号：US20160274126A1

  公开（公告）日：2016-09-22

  Disclosed are methods for the detection or diagnosis of a patient having symptoms of interstitial cystitis or overactive bladder. Also disclosed are HCN2 modulators and methods for the treatment of interstitial cystitis or overactive bladder.
• [EN] BIOMARKERS FOR THE DIAGNOSIS OF INTERSTITIAL CYSTITIS<br/>[FR] BIOMARQUEURS POUR LE DIAGNOSTIC DE LA CYSTITE INTERSTITIELLE
  申请人：BEAUMONT HOSPITAL WILLIAM

  公开号：WO2014078232A1

  公开（公告）日：2014-05-22

  Disclosed are methods for the detection or diagnosis of a patient having symptoms of interstitial cystitis or overactive bladder. Also disclosed are HCN2 modulators and methods for the treatment of interstitial cystitis or overactive bladder.