N-(2-aminoethyl)-4-methoxy-N-propan-2-ylbenzamide | 1018266-22-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2-aminoethyl)-4-methoxy-N-propan-2-ylbenzamide
• CAS: 1018266-22-2
• 化学式: C₁₃H₂₀N₂O₂
• 分子量: 236.314
• InChiKey: GDOJHOYENBAUMR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  55.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(2-aminoethyl)-4-methoxy-N-propan-2-ylbenzamide 生成 4-methoxy-N-[2-(propan-2-ylamino)ethyl]benzamide
  参考文献：
  名称：

  A NOVEL PROTECTING STRATEGY FOR INTERNUCLEOSIDIC PHOSPHATE AND PHOSPHOROTHIOATE GROUPS

  摘要：

  The utility of 2-(N-isopropyl-N-anisoylamino)ethyl group for protection of internucleosidic phosphate linkages in oligonucleotide synthesis was studied. The group demonstrated high coupling yields, favorable deprotection kinetics and a high hydrolytic stability of phosphoramidite building blocks. The mechanism of deprotection was established using a model phosphate triester.

  DOI：

  10.1081/ncn-100002480
• 作为产物：
  描述：

  O,O-diethyl-O-[2-[N-isopropyl-N-(4-methoxybenzoyl)amino]ethyl]phosphate 在 ammonium hydroxide 作用下， 生成 N-(2-aminoethyl)-4-methoxy-N-propan-2-ylbenzamide
  参考文献：
  名称：

  A NOVEL PROTECTING STRATEGY FOR INTERNUCLEOSIDIC PHOSPHATE AND PHOSPHOROTHIOATE GROUPS

  摘要：

  The utility of 2-(N-isopropyl-N-anisoylamino)ethyl group for protection of internucleosidic phosphate linkages in oligonucleotide synthesis was studied. The group demonstrated high coupling yields, favorable deprotection kinetics and a high hydrolytic stability of phosphoramidite building blocks. The mechanism of deprotection was established using a model phosphate triester.

  DOI：

  10.1081/ncn-100002480

文献信息

• A NOVEL PROTECTING STRATEGY FOR INTERNUCLEOSIDIC PHOSPHATE AND PHOSPHOROTHIOATE GROUPS
  作者：Andrei P. Guzaev、Muthiah Manoharan

  DOI：10.1081/ncn-100002480

  日期：2001.3.31

  The utility of 2-(N-isopropyl-N-anisoylamino)ethyl group for protection of internucleosidic phosphate linkages in oligonucleotide synthesis was studied. The group demonstrated high coupling yields, favorable deprotection kinetics and a high hydrolytic stability of phosphoramidite building blocks. The mechanism of deprotection was established using a model phosphate triester.