1-[(2R,3R,4R)-3-fluoro-4-hydroxy-3-methyloxolan-2-yl]pyrimidine-2,4-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 1-[(2R,3R,4R)-3-fluoro-4-hydroxy-3-methyloxolan-2-yl]pyrimidine-2,4-dione
• 化学式: C₉H₁₁FN₂O₄
• 分子量: 230.19
• InChiKey: XGOFSAVUMZXSNO-SLBFFKMLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  78.9
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] 4'-FLUORO-2'-METHYL SUBSTITUTED NUCLEOSIDE DERIVATIVES AS INHIBITORS OF HCV RNA REPLICATION<br/>[FR] DÉRIVÉS NUCLÉOSIDIQUES À SUBSTITUTION 4'-FLUORO-2'-MÉTHYLE UTILISÉS COMME INHIBITEURS DE LA RÉPLICATION DE L'ARN DU VHC
  申请人：RIBOSCIENCE LLC

  公开号：WO2019060740A1

  公开（公告）日：2019-03-28

  Cytidine nucleoside analogues of Formula I, wherein the variables are as described herein, in combination with uridine nucleoside analogues of Formula II, wherein the variables are as described herein, produce a synergistic effect on the inhibition of HCV polymerase.

  Cytidine核苷类似物的化学式I，其中变量如本文所述，与尿苷核苷类似物的化学式II，其中变量如本文所述，对HCV聚合酶的抑制产生协同作用。
• Nucleoside phosphoramidate prodrugs
  申请人：Gilead Pharmasset LLC

  公开号：EP2801580A1

  公开（公告）日：2014-11-12

  Disclosed herein are phosphoramidate prodrugs of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound or its stereoisomer, represented by the following structure: Also disclosed are uses and processes for preparing the compound represented by formula I.

  本文公开了用于治疗哺乳动物病毒感染的核苷衍生物磷酰胺原药，它是由以下结构表示的化合物或其立体异构体： 还公开了制备式 I 所表示的化合物的用途和工艺。
• 4′-fluoro-2′-methyl substituted nucleoside derivatives as inhibitors of HCV RNA replication
  申请人：Riboscience LLC

  公开号：US10682369B2

  公开（公告）日：2020-06-16

  Cytidine nucleoside analogues of Formula I, wherein the variables are as described herein, in combination with uridine nucleoside analogues of Formula II, wherein the variables are as described herein, produce a synergistic effect on the inhibition of HCV polymerase.

  式 I 的胞苷核苷类似物（其中变量如本文所述）与式 II 的尿苷核苷类似物（其中变量如本文所述）的组合、 可产生抑制 HCV 聚合酶的协同效应。
• NUCLEOSIDE PHOSPHORAMIDATE PRODRUGS
  申请人：Gilead Pharmasset LLC

  公开号：EP2203462B1

  公开（公告）日：2014-05-21
• SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF FOR USE IN THE TREATMENT OF VIRAL INFECTION
  申请人：Janssen BioPharma, Inc.

  公开号：EP3160476B1

  公开（公告）日：2020-09-30