2-(N-(2-chlorophenyl)anilino)-N-(7-oxooctyl)pyrimidine-5-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-(N-(2-chlorophenyl)anilino)-N-(7-oxooctyl)pyrimidine-5-carboxamide
• 化学式: C₂₅H₂₇ClN₄O₂
• 分子量: 451.0
• InChiKey: FUBXEGCYRJZNTL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  32
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  75.2
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• REVERSE AMIDE COMPOUNDS AS PROTEIN DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF
  申请人：Acetylon Pharmaceuticals

  公开号：US20140142117A1

  公开（公告）日：2014-05-22

  The present invention relates to novel “reverse amide” compounds comprising a zinc chelator group, and the use of such compounds in the inhibition of HDAC6 and in the treatment of various diseases, disorders or conditions related to HDAC6.
• Histone Deacetylase 6 Selective Inhibitors for the Treatment of Bone Disease
  申请人：Raje Noopur

  公开号：US20140378385A1

  公开（公告）日：2014-12-25

  This invention relates to methods for treating bone disease associated with osteoclast activation using HDAC6 selective inhibitors, e.g., small molecule inhibitors such as reverse amide compounds.
• US9512083B2
  申请人：——

  公开号：US9512083B2

  公开（公告）日：2016-12-06