(E)-4-((2-(2-(benzo[d]thiazol-2-yl)-2-cyanovinyl)-5-(diethylamino)phenoxy)methyl)phenyl diethyl phosphate | 1429015-60-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: (E)-4-((2-(2-(benzo[d]thiazol-2-yl)-2-cyanovinyl)-5-(diethylamino)phenoxy)methyl)phenyl diethyl phosphate
• 英文别名: [4-[[2-[(E)-2-(1,3-benzothiazol-2-yl)-2-cyanoethenyl]-5-(diethylamino)phenoxy]methyl]phenyl] diethyl phosphate
• CAS: 1429015-60-0
• 化学式: C₃₁H₃₄N₃O₅PS
• 分子量: 591.668
• InChiKey: VAPSKNPBERTTIH-NCELDCMTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  41
• 可旋转键数：
  14
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  122
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  (E)-4-((2-(2-(benzo[d]thiazol-2-yl)-2-cyanovinyl)-5-(diethylamino)phenoxy)methyl)phenyl diethyl phosphate 在 三甲基溴硅烷 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 生成
  参考文献：
  名称：

  An improved fluorogenic substrate for the detection of alkaline phosphatase activity

  摘要：

  We designed a new alkaline phosphatase (ALP)-sensitive fluorogenic probe in which a self-immolative spacer group, p-hydroxybenzyl alcohol, is linked to a profluorogenic compound to improve substrate specificity. Enzymatic hydrolysis converts the fluorogenic substrate 1 to a highly fluorescent reporter 3, thus allowing for the fast and quantitative analysis of ALP activity with greatly increased affinity for the enzyme. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.02.063
• 作为产物：
  描述：

  diethyl 4-(hydroxymethyl)phenyl phosphate 在 哌啶 、 四溴化碳 、 potassium carbonate 、 三苯基膦 作用下， 以 乙醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 7.0h， 生成 (E)-4-((2-(2-(benzo[d]thiazol-2-yl)-2-cyanovinyl)-5-(diethylamino)phenoxy)methyl)phenyl diethyl phosphate
  参考文献：
  名称：

  An improved fluorogenic substrate for the detection of alkaline phosphatase activity

  摘要：

  We designed a new alkaline phosphatase (ALP)-sensitive fluorogenic probe in which a self-immolative spacer group, p-hydroxybenzyl alcohol, is linked to a profluorogenic compound to improve substrate specificity. Enzymatic hydrolysis converts the fluorogenic substrate 1 to a highly fluorescent reporter 3, thus allowing for the fast and quantitative analysis of ALP activity with greatly increased affinity for the enzyme. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.02.063

文献信息

• An improved fluorogenic substrate for the detection of alkaline phosphatase activity
  作者：Jeesook Park、Youngmi Kim

  DOI：10.1016/j.bmcl.2013.02.063

  日期：2013.4

  We designed a new alkaline phosphatase (ALP)-sensitive fluorogenic probe in which a self-immolative spacer group, p-hydroxybenzyl alcohol, is linked to a profluorogenic compound to improve substrate specificity. Enzymatic hydrolysis converts the fluorogenic substrate 1 to a highly fluorescent reporter 3, thus allowing for the fast and quantitative analysis of ALP activity with greatly increased affinity for the enzyme. (C) 2013 Elsevier Ltd. All rights reserved.