N-[5-(3-azidoimidazo[1,2-b]pyridazin-6-yl)-2-methoxypyridin-3-yl]-2,4-difluorobenzenesulfonamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: N-[5-(3-azidoimidazo[1,2-b]pyridazin-6-yl)-2-methoxypyridin-3-yl]-2,4-difluorobenzenesulfonamide
• 化学式: C18H12F2N8O3S
• 分子量: 458.4
• InChiKey: YQZPJIMFFMVYIQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  121
• 氢给体数：
  1
• 氢受体数：
  11

文献信息

• US9926324B2
  申请人：——

  公开号：US9926324B2

  公开（公告）日：2018-03-27
• [EN] HETEROAROMATIC COMPOUNDS AS PI3 KINASE MODULATORS AND METHODS OF USE<br/>[FR] COMPOSÉS HÉTÉROAROMATIQUES À TITRE DE MODULATEURS DES PI3 KINASES ET LEURS MÉTHODES D'UTILISATION
  申请人：CALITOR SCIENCES LLC

  公开号：WO2014078211A1

  公开（公告）日：2014-05-22

  The present invention provides heteroaromatic derivatives and pharmaceutical acceptable salts and formulations thereof useful in modulating the protein kinase activity, especially phosphatidylinositol 3-kinases (PI3 kinases) and mTOR, and in modulating inter- and/or intra-cellular signaling activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.