N-{2-[hydroxy(phenyl)methyl]-4-(methoxymethyl)-6-methylthieno[2,3-b]pyridin-3-yl}benzamide | 442647-46-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并吡啶类
• 英文名称: N-{2-[hydroxy(phenyl)methyl]-4-(methoxymethyl)-6-methylthieno[2,3-b]pyridin-3-yl}benzamide
• 英文别名: N-[2-[hydroxy(phenyl)methyl]-4-(methoxymethyl)-6-methylthieno[2,3-b]pyridin-3-yl]benzamide
• CAS: 442647-46-3
• 化学式: C₂₄H₂₂N₂O₃S
• 分子量: 418.516
• InChiKey: GXEBDJKEKRPFJI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  99.7
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-甲基呋喃 、 N-{2-[hydroxy(phenyl)methyl]-4-(methoxymethyl)-6-methylthieno[2,3-b]pyridin-3-yl}benzamide 在 高氯酸 、 乙酸酐 、 溶剂黄146 作用下， 以 1,4-二氧六环 、 水 为溶剂， 以75%的产率得到
  参考文献：
  名称：

  Phenylfurylthieno[2,3-b]pyridyl-methanes. synthesis and reactions of the furan ring transformation

  摘要：

  Triarylmethane derivatives with various substituents, phenyl, 5-methyl-2-furyl, and 3-acylaminothieno[2,3-b] pyrid-2-yl have been obtained for the first time. The behavior of these compounds under protolytic conditions has been studied. It was shown that the character of the protection of the amino group of the thienopyridine fragment affects the type of transformation of the furan ring.

  DOI：

  10.1007/s10593-009-0401-9
• 作为产物：
  描述：

  N-[2-benzoyl-4-(methoxymethyl)-6-methylthieno[2,3-b]pyridin-3-yl]benzamide 在 sodium tetrahydroborate 作用下， 以 乙醇 为溶剂， 生成 N-{2-[hydroxy(phenyl)methyl]-4-(methoxymethyl)-6-methylthieno[2,3-b]pyridin-3-yl}benzamide
  参考文献：
  名称：

  Phenylfurylthieno[2,3-b]pyridyl-methanes. synthesis and reactions of the furan ring transformation

  摘要：

  Triarylmethane derivatives with various substituents, phenyl, 5-methyl-2-furyl, and 3-acylaminothieno[2,3-b] pyrid-2-yl have been obtained for the first time. The behavior of these compounds under protolytic conditions has been studied. It was shown that the character of the protection of the amino group of the thienopyridine fragment affects the type of transformation of the furan ring.

  DOI：

  10.1007/s10593-009-0401-9

文献信息

• Synthesis and reactivity of thieno[2,3-b]pyridine-2,3-diamines
  作者：M. M. Lipunov、E. A. Kaigorodova、L. D. Konyushkin、S. I. Firgang、G. D. Krapivin

  DOI：10.1007/s10593-007-0182-y

  日期：2007.9