[(2R,3S,4R,5R)-5-(4-acetamido-5-ethyl-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷酸
• 英文名称: [(2R,3S,4R,5R)-5-(4-acetamido-5-ethyl-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate
• 化学式: C₁₃H₂₀N₃O₉P
• 分子量: 393.29
• InChiKey: IXEFLXMMPDEIHG-DNRKLUKYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  178
• 氢给体数：
  5
• 氢受体数：
  9

文献信息

• MODIFIED POLYNUCLEOTIDES ENCODING APOPTOSIS INDUCING FACTOR 1
  申请人：Bancel Stephane

  公开号：US20140107189A1

  公开（公告）日：2014-04-17

  The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of oncology-related polynucleotides, oncology-related primary transcripts and oncology-related mmRNA molecules.
• MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF PROTEINS ASSOCIATED WITH BLOOD AND LYMPHATIC DISORDERS
  申请人：Bancel Stephane

  公开号：US20140147432A1

  公开（公告）日：2014-05-29

  The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
• MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF
  申请人：MODERNA THERAPEUTICS, INC.

  公开号：US20160304552A1

  公开（公告）日：2016-10-20

  The present disclosure provides modified nucleosides, nucleotides, and nucleic acids, and methods of using them.
• US9114113B2
  申请人：——

  公开号：US9114113B2

  公开（公告）日：2015-08-25
• US9220755B2
  申请人：——

  公开号：US9220755B2

  公开（公告）日：2015-12-29