Chloroform;pyrene

• 分子结构分类: 有机化合物 - 苯类化合物 - 芘
• 英文名称: Chloroform;pyrene
• 英文别名: chloroform;pyrene
• 化学式: C17H11Cl3
• 分子量: 321.6
• InChiKey: OTCJNTMLRFDHPV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.57
• 重原子数：
  20
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

文献信息

• [EN] INTRACELLULAR DELIVERY AND MITOCHONDRIAL TARGETING BY FLUORINATION<br/>[FR] ADMINISTRATION INTRACELLULAIRE ET CIBLAGE MITOCHONDRIAL PAR FLUORATION
  申请人：TEXAS A & M UNIV SYS

  公开号：WO2020198646A1

  公开（公告）日：2020-10-01

  In an embodiment, the present disclosure relates to a targeting platform that includes a targeted delivery system including an agent. In some embodiments, the targeted delivery system is modified by fluorination. In some embodiments, the targeted delivery system is electrically charge neutral. In a further embodiment, the present disclosure relates to a method that includes fluorinating a targeting compound with a fluorinating reagent and loading an agent with the fluorinated targeting compound to thereby form a micelle. In an additional embodiment, the present disclosure relates to a targeting platform that includes a fluorinated polymeric system including an agent. In another embodiment, the present disclosure relates to a method that includes fluorinating a targeting compound with a fluorinating reagent and loading an agent with the fluorinated targeting compound to thereby form a micelle. Additionally, the method can include administering the fluorinated targeting compound to a subject.

  在一种实施例中，本公开涉及一种包括代理的定位平台，其中包括一个定向传递系统。在某些实施例中，定向传递系统通过氟化进行修改。在某些实施例中，定向传递系统具有电荷中性。在另一种实施例中，本公开涉及一种方法，其中包括使用氟化试剂氟化定向化合物，并使用氟化定向化合物装载代理以形成胶束。在另一种实施例中，本公开涉及一种包括含有代理的氟化聚合物系统的定位平台。此外，该方法可以包括将氟化定向化合物用于治疗对象。
• [EN] COPOLYMERS FOR THE DELIVERY OF DRUGS INTO CELLS<br/>[FR] COPOLYMÈRES POUR L'ADMINISTRATION DE MÉDICAMENTS DANS DES CELLULES
  申请人：UNIV NORTHEASTERN

  公开号：WO2014085579A1

  公开（公告）日：2014-06-05

  Provided is a co-polymer of formula A-B-C or a pharmaceutically acceptable salt thereof, where A comprises a water soluble polymer; B comprises a matrix metalloprotease (MMP)-cleavable polypeptide; C is a chemotherapeutic drug or a derivative thereof; and A is connected to B at a first end through a first covalent bond or a first linking moiety and B is connected to C at a second end through a second covalent bond or a second linking moiety, where the co-polymer is not cross-linked.

  提供的是公式A-B-C的共聚物或其药学上可接受的盐，其中A包括水溶性聚合物；B包括基质金属蛋白酶（MMP）可降解的多肽；C是化疗药物或其衍生物；A通过第一共价键或第一连接基团连接到B的第一端，而B通过第二共价键或第二连接基团连接到C的第二端，其中共聚物未交联。
• COPOLYMERS FOR THE DELIVERY OF DRUGS INTO CELLS
  申请人：NORTHEASTERN UNIVERSITY

  公开号：US20150306241A1

  公开（公告）日：2015-10-29

  Provided is a co-polymer of formula A-B-C or a pharmaceutically acceptable salt thereof, where A comprises a water soluble polymer; B comprises a matrix metalloprotease (MMP)-cleavable polypeptide; C is a chemotherapeutic drug or a derivative thereof; and A is connected to B at a first end through a first covalent bond or a first linking moiety and B is connected to C at a second end through a second covalent bond or a second linking moiety, where the co-polymer is not cross-linked.
• SYSTEM FOR CO-DELIVERY OF POLYNUCLEOTIDES AND DRUGS INTO PROTEASE-EXPRESSING CELLS
  申请人：NORTHEASTERN UNIVERSITY

  公开号：US20160312218A1

  公开（公告）日：2016-10-27

  Nanoparticle compositions and pharmaceutical compositions for the delivery of a polynucleotide and a hydrophobic pharmaceutical agent to a cell or tissue that overexpresses a protease are provided. Methods of making such compositions and methods of using such composition to treat a condition associated with a cell or tissue that overexpresses a protease are provided as well. Also provided are kits for use in treating a condition associated with a cell or tissue that overexpresses a protease. The compositions, methods, and kits can be used to selectively deliver anti-tumor agents to cancer cells.
• INTRACELLULAR DELIVERY AND MITOCHONDRIAL TARGETING BY FLUORINATION
  申请人：The Texas A&M University System

  公开号：US20220152226A1

  公开（公告）日：2022-05-19

  In an embodiment, the present disclosure relates to a targeting platform that includes a targeted delivery system including an agent. In some embodiments, the targeted delivery system is modified by fluorination. In some embodiments, the targeted delivery system is electrically charge neutral. In a further embodiment, the present disclosure relates to a method that includes fluorinating a targeting compound with a fluorinating reagent and loading an agent with the fluorinated targeting compound to thereby form a micelle. In an additional embodiment, the present disclosure relates to a targeting platform that includes a fluorinated polymeric system including an agent. In another embodiment, the present disclosure relates to a method that includes fluorinating a targeting compound with a fluorinating reagent and loading an agent with the fluorinated targeting compound to thereby form a micelle. Additionally, the method can include administering the fluorinated targeting compound to a subject.