4,5-ditert-butyl-4,5-dihydro-1H-pyrimidin-6-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4,5-ditert-butyl-4,5-dihydro-1H-pyrimidin-6-one
• 化学式: C₁₂H₂₂N₂O
• 分子量: 210.32
• InChiKey: JHLBCWIJHFPNAI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  41.5
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• BICYCLIC INHIBITORS OF ALK
  申请人：Vasudevan Anil

  公开号：US20140171429A1

  公开（公告）日：2014-06-19

  The present invention relates to compounds of formula (1) or pharmaceutical acceptable salts, Formula (1) wherein R 1 , R 2 , R 3 , X, Y, Z, A, B, G 1 , m, and n are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as ALK and methods of treating diseases such as cancer.

  本发明涉及式(1)的化合物或药用可接受的盐，式(1)中R1、R2、R3、X、Y、Z、A、B、G1、m和n的定义在说明中。本发明还涉及含有所述化合物的组合物，用于抑制激酶如ALK以及治疗癌症等疾病的方法。
• CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTICS DELIVERY
  申请人：CERULEAN PHARMA INC.

  公开号：US20130156721A1

  公开（公告）日：2013-06-20

  The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.

  本发明涉及一种新型治疗环糊精含聚合物的组合物，设计为小分子治疗药物输送的载体以及其制药组合物。这些含环糊精的聚合物能够提高药物稳定性和溶解度，并在体内使用时减少小分子治疗药物的毒性。此外，通过从多种连接剂和靶向配体中选择聚合物，可以提供治疗剂的控制释放方法。本发明还涉及使用上述治疗组合物治疗受试者的方法。本发明还涉及制药业务的方法，包括制造、许可或分发包含或与上述聚合物相关的工具包。