5-甲基-2-吡啶羧酸盐酸盐 | 177359-60-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 5-甲基-2-吡啶羧酸盐酸盐
• 中文别名: 5-甲基吡啶-2-羧酸盐酸盐
• 英文名称: 5-methyl-pyridine-2-carboxylic acid hydrochloride
• 英文别名: 2-carboxy-5-methylpyridinium chloride；5-Methylpicolinic acid hydrochloride；5-methylpyridine-2-carboxylic acid;hydrochloride
• CAS: 177359-60-3
• 化学式: C₇H₇NO₂*ClH
• mdl: MFCD20040409
• 分子量: 173.599
• InChiKey: JNFOZAYGOQOYAB-UHFFFAOYSA-N

物化性质

• 熔点：
  135 °C

计算性质

• 辛醇/水分配系数(LogP)：
  -0.19
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.142
• 拓扑面积：
  51.4
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2933399090
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

反应信息

• 作为反应物：
  描述：

  5-甲基-2-吡啶羧酸盐酸盐 在 platinum(IV) oxide 氢气 作用下， 以 乙醇 为溶剂， 反应 48.0h， 以100%的产率得到5-methyl-piperidine-2-carboxylic acid hydrochloride
  参考文献：
  名称：

  [EN] COMPOUNDS HAVING AN ACTIVITY AT METABOTROPIC GLUTAMATE RECEPTORS
  [FR] NOUVEAUX COMPOSES

  摘要：

  公开号：

  WO2004014902A3
• 作为产物：
  描述：

  2-氰基-5-甲基吡啶 在 盐酸 作用下， 以 乙醇 、 水 为溶剂， 反应 40.0h， 生成 5-甲基-2-吡啶羧酸盐酸盐
  参考文献：
  名称：

  [EN] COMPOUNDS HAVING AN ACTIVITY AT METABOTROPIC GLUTAMATE RECEPTORS
  [FR] NOUVEAUX COMPOSES

  摘要：

  公开号：

  WO2004014902A3

文献信息

• Substituted thiazolo \x9b3,2-a!azepine derivatives
  申请人：Eisai Co., Ltd.

  公开号：US05789403A1

  公开（公告）日：1998-08-04

  The present invention relates to a substituted thiazolo\x9b3,2-a!azepine derivative having inhibitory activity against angiotensin I converting enzyme and neutral endpeptidase. The above substituted thiazolo\x9b3,2-a!azepine derivative is represented by the following general formula (I): ##STR1## (wherein R1 represents a hydrogen atom or a protecting group of a thiol group; R2 represents a hydrogen atom, a lower alkyl group, an aryl group which may have a substituent, a hetroaryl group which may have a substituent, a lower alkoxyl group or a lower alkylthio group; R3, R4 and R5 may be the same or different from one another and represent each a hydrogen atom, a lower alkyl group, a lower alkoxyl group, a lower alkylthio group or the like, with the proviso that the case wherein all of R3, R4 and R5 are hydrogen atoms are excepted; R6 and R7 may be the same or different from each other and represent each a hydrogen atom or a lower alkyl group; R8 represents a hydrogen atom or a protecting group of a carboxyl group; and m and m are each independently 0 or, 1 or 2).

  本发明涉及一种取代的噻唑并[3,2-a]氮杂七环衍生物，具有抑制血管紧张素I转化酶和中性内肽酶的活性。上述取代的噻唑并[3,2-a]氮杂七环衍生物由以下通式(I)表示： ##STR1## （其中，R1表示氢原子或硫醇基的保护基；R2表示氢原子、较低的烷基、可能具有取代基的芳基、可能具有取代基的杂芳基、较低的烷氧基或较低的烷硫基；R3、R4和R5可以相同也可以不同，分别表示氢原子、较低的烷基、较低的烷氧基、较低的烷硫基或类似物，但三个基团都是氢原子的情况除外；R6和R7可以相同也可以不同，分别表示氢原子或较低的烷基；R8表示氢原子或羧基的保护基；m和n各自独立地为0或1或2）。
• New compounds
  申请人：AstraZeneca AB and NPS Pharmaceuticals, Inc.

  公开号：US20040106607A1

  公开（公告）日：2004-06-03

  The present invention relates to new compounds of formula I, 1 wherein P, Q, X 1 , X 2 , X 3 , X 4 , X 5 , R, R 1 , R 2 , R 3 , R 4 , R 5 , G, M 1 , M 2 , M 3 , m and n, are defined as in formula I, a process for their preparation and new intermediates prepared therein, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy.

  本发明涉及公式I的新化合物，其中P、Q、X1、X2、X3、X4、X5、R、R1、R2、R3、R4、R5、G、M1、M2、M3、m和n在公式I中定义，以及其制备过程和其中制备的新中间体，含有所述化合物的药物配方以及在治疗中使用所述化合物的用途。
• SUBSTITUTED THIAZOLO [3,2-ALPHA]AZEPINE DERIVATIVE
  申请人：Eisai Co., Ltd.

  公开号：EP0719779A1

  公开（公告）日：1996-07-03

  The present invention relates to a substituted thiazolo[3,2-a]azepine derivative having inhibitory activity against angiotensin I converting enzyme and neutral endpeptidase. The above substituted thiazolo[3,2-a]azepine derivative is represented by the following general formula (I):    (wherein R1 represents a hydrogen atom or a protecting group of a thiol group; R2 represents a hydrogen atom, a lower alkyl group, an aryl group which may have a substituent, a hetroaryl group which may have a substituent, a lower alkoxyl group or a lower alkylthio group; R3, R4 and R5 may be the same or different from one another and represent each a hydrogen atom, a lower alkyl group, a lower alkoxyl group, a lower alkylthio group or the like, with the proviso that the case wherein all of R3, R4 and R5 are hydrogen atoms are excepted;    R6 and R7 may be the same or different from each other and represent each a hydrogen atom or a lower alkyl group; R8 represents a hydrogen atom or a protecting group of a carboxyl group; and    m and m are each independently 0 or, 1 or 2).

  本发明涉及一种取代的噻唑并[3,2-a]氮杂卓衍生物，它对血管紧张素 I 转换酶和中性内肽酶具有抑制活性。 上述取代的噻唑并[3,2-a]氮杂卓衍生物由以下通式（I）表示： (其中 R1 代表氢原子或硫醇基的保护基团；R2 代表氢原子、低级烷基、可能具有取代基的芳基、可能具有取代基的己基芳基、低级烷氧基或低级烷硫基；R3、R4 和 R5 可以相同或不同，各自代表氢原子、低级烷基、低级烷氧基、低级烷硫基或类似基团，但 R3、R4 和 R5 全为氢原子的情况除外； R6 和 R7 可以相同或不同，各自代表氢原子或低级烷基；R8 代表氢原子或羧基的保护基；以及 m和m各自独立地为0或、1或2）。
• One-Pot Double Benzylation of 2-Substituted Pyridines using Palladium-Catalyzed Decarboxylative Coupling of<i>sp</i>²and<i>sp</i>³Carbons
  作者：Yaping Wang、Xinjian Li、Faqiang Leng、Helong Zhu、Jingya Li、Dapeng Zou、Yangjie Wu、Yusheng Wu

  DOI：10.1002/adsc.201400311

  日期：2014.11.3

  AbstractAn efficient and practical decarboxylative double benzylation method for various 2‐picolinic acids has been established by using a bimetallic catalytic system of palladium(II) chloride (PdCl2) and silver(I) oxide (Ag2O), which offered a variety of diarylmethane derivatives with moderate to good yields.magnified image
• COMPOUNDS HAVING AN ACTIVITY AT METABOTROPIC GLUTAMATE RECEPTORS
  申请人：AstraZeneca AB

  公开号：EP1581525A2

  公开（公告）日：2005-10-05