3-[4-[4-[4-[(3-Chlorophenyl)carbamoylamino]phenyl]thieno[3,2-d]pyrimidin-7-yl]phenyl]-2-methylpropanoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 3-[4-[4-[4-[(3-Chlorophenyl)carbamoylamino]phenyl]thieno[3,2-d]pyrimidin-7-yl]phenyl]-2-methylpropanoic acid
• 英文别名: 3-[4-[4-[4-[(3-chlorophenyl)carbamoylamino]phenyl]thieno[3,2-d]pyrimidin-7-yl]phenyl]-2-methylpropanoic acid
• 化学式: C₂₉H₂₃ClN₄O₃S
• 分子量: 543.0
• InChiKey: HSJWHCKUHYZNHQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  38
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  132
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• NOVEL PYRIMIDINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION INCLUDING SAME AS AN ACTIVE INGREDIENT
  申请人：Park Chul Hyun

  公开号：US20140163226A1

  公开（公告）日：2014-06-12

  The present invention relates to a compound represented by formula (I) for inhibiting the activity of diacylglycerol O-acyltransferase type 1 (DGAT1), and pharmaceutically acceptable salts thereof, and a pharmaceutical composition comprising same as an active ingredient. The compound of the present invention may be used effectively in the treatment or prevention of a disease or condition mediated by the activity of DGAT1 such as obesity, type II diabetes, dyslipidemia, metabolic syndrome, and the like, without any adverse effects: wherein A, B, X, and R 5 to R 7 are the same as defined in the specification.

  本发明涉及一种由式(I)表示的化合物，用于抑制二酰基甘油O-酰基转移酶1型（DGAT1）的活性，以及其药学上可接受的盐，以及包含其作为活性成分的药物组合物。本发明的化合物可有效用于治疗或预防由DGAT1活性介导的疾病或症状，如肥胖、2型糖尿病、血脂异常、代谢综合征等，而不产生任何不良影响：其中A、B、X和R5至R7与规范中定义的相同。