((6-methoxynaphthalen-2-yl)ethynyl)(trifluoromethyl)sulfane | 1388753-78-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: ((6-methoxynaphthalen-2-yl)ethynyl)(trifluoromethyl)sulfane
• 英文别名: 2-Methoxy-6-[2-(trifluoromethylsulfanyl)ethynyl]naphthalene；2-methoxy-6-[2-(trifluoromethylsulfanyl)ethynyl]naphthalene
• CAS: 1388753-78-3
• 化学式: C₁₄H₉F₃OS
• 分子量: 282.286
• InChiKey: NBRKHMQZPLSEPU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  34.5
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  异戊醛 、 ((6-methoxynaphthalen-2-yl)ethynyl)(trifluoromethyl)sulfane 在 tetrakis(tetrabutylammonium)decatungstate(VI) 作用下， 以 水 、 乙腈 为溶剂， 以59 %的产率得到3-(6-methoxynaphthalen-2-yl)-4,4-dimethyl-2-((trifluoromethyl)thio)cyclopentan-1-one
  参考文献：
  名称：

  10.1002/anie.202407689

  摘要：

  A photocatalyzed formal (3+2) cycloaddition has been developed to construct original polysubstituted α‐SCF3 cyclopentanones in a regio‐ and diastereoselective manner. This building block approach leverages trifluoromethylthio alkynes and branched / linear aldehydes, as readily available reaction partners, in consecutive hydrogen atom transfers and C–C bond formations. Difluoromethylthio alkynes are also compatible subtrates. Furthermore, the potential for telescoped reaction starting from alcohols instead of aldehydes was demonstrated, as well as process automatization and scale‐up under continuous microflow conditions. This prompted density functional theory calculations to support a free radical‐mediated cascade hydrogen atom transfer process.

  DOI：

  10.1002/anie.202407689
• 作为产物：
  描述：

  2-乙炔基-6-甲氧基萘 、 (三氟甲硫基)银(I) 在 potassium phosphate 、 N-氯代丁二酰亚胺 作用下， 以 N,N-二甲基乙酰胺 为溶剂， 以76%的产率得到((6-methoxynaphthalen-2-yl)ethynyl)(trifluoromethyl)sulfane
  参考文献：
  名称：

  末端炔烃与 AgSCF3 的氧化三氟甲基硫醇化：一种方便的方法来制备炔基三氟甲基硫化物

  摘要：

  开发了一种高效合成炔基三氟甲基硫化物的新方法。通过在 N,N-二甲基乙酰胺中结合 AgSCF3 和 NCS，产生了亲电活性中间体，然后用各种末端炔烃处理，以中等至极好的收率提供相应的三氟甲磺酰化产物。

  DOI：

  10.1002/ejoc.201402533

文献信息

• Metal-Free Oxidative Trifluoromethylthiolation of Terminal Alkynes with CF₃SiMe₃ and Elemental Sulfur
  作者：Chao Chen、Lingling Chu、Feng-Ling Qing

  DOI：10.1021/ja305801m

  日期：2012.8.1

  A metal-free oxidative trifluoromethyl-thiolation of terminal alkynes using readily available CF(3)SiMe(3) and elemental sulfur at room temperature has been developed. This reaction provides an efficient and convenient method for the preparation of alkynyl trifluoromethyl sulfides bearing a wide range of functional groups. Preliminary investigation revealed that elemental sulfur instead of air acted

  已经开发出在室温下使用现成的 CF(3)SiMe(3) 和元素硫对末端炔烃进行无金属氧化三氟甲基硫醇化。该反应为制备具有广泛官能团的炔基三氟甲基硫化物提供了一种高效便捷的方法。初步调查显示元素硫代替空气充当氧化剂。
• Difluorocarbene-based trifluoromethylthiolation of terminal alkynes
  作者：Guowen He、Yan-Hua Jiang、Xuan Xiao、Jin-Hong Lin、Xing Zheng、Ruo-Bing Du、Yu-Cai Cao、Ji-Chang Xiao

  DOI：10.1016/j.jfluchem.2019.109437

  日期：2020.2

  A large number of trifluoromethylthiolation methods have been developed, but a trifluoromethylthiolation reagent usually has to be used in these methods. Herein we describe a difluorocarbene-based trifluoromethylthiolation of terminal alkynes to construct a Csp-SCF3 bond catalysed by a copper complex. Ph3P+CF2CO2-/S8/F- was used as a reagent system to form the CF3S- anion, and the sequential formation

  已经开发了大量的三氟甲基硫醇化方法，但是在这些方法中通常必须使用三氟甲基硫醇化试剂。在本文中，我们描述了末端炔烃的基于二氟卡宾的三氟甲基硫醇化，以构建由铜配合物催化的Csp-SCF 3键。用Ph 3 P + CF 2 CO 2- / S 8 / F-作为试剂体系形成CF 3 S-阴离子，依次形成CF 2 = S，F-CF 2 S和C-SCF 3一步一步就可以实现纽带。
• Direct Catalytic Trifluoromethylthiolation of Boronic Acids and Alkynes Employing Electrophilic Shelf-Stable<i>N</i>-(trifluoromethylthio)phthalimide
  作者：Roman Pluta、Pavlo Nikolaienko、Magnus Rueping

  DOI：10.1002/anie.201307484

  日期：2014.2.3

  for the synthesis of N‐(trifluoromethylthio)phthalimide, a convenient and shelf‐stable reagent for the direct trifluoromethylthiolation, has been developed. N‐(Trifluoromethylthio)phthalimide can be used as an electrophilic source of F3CS+ and reacts readily with boronic acids and alkynes under copper catalysis. The utility of CF3S‐containing molecules as biologically active agents, the mild reaction

  已开发出一种新的安全的合成N-（三氟甲基硫代）邻苯二甲酰亚胺的方法，N-（三氟甲基硫代）邻苯二甲酰亚胺是一种方便且稳定的直接三氟甲基硫代化试剂。N-（三氟甲硫基）邻苯二甲酰亚胺可用作F 3 CS +的亲电子源，并在铜催化下易于与硼酸和炔烃反应。含有CF 3 S的分子作为生物活性剂的实用性，所采用的反应条件温和以及对官能团的高度耐受性证明了这种新方法在有机合成以及工业制药和农用化学研究以及发展。
• Oxidative Trifluoromethylthiolation of Terminal Alkynes with AgSCF₃: A Convenient Approach to Alkynyl Trifluoromethyl Sulfides
  作者：Sheng-Qing Zhu、Xiu-Hua Xu、Feng-Ling Qing

  DOI：10.1002/ejoc.201402533

  日期：2014.7

  new method for the efficient synthesis of alkynyl trifluoromethyl sulfides was developed. By combining AgSCF3 and NCS in N,N-dimethylacetamide, an electrophilic active intermediate was produced, which was then treated with a variety of terminal alkynes to afford the corresponding trifluoromethanesulfenylated products in moderate to excellent yields.

  开发了一种高效合成炔基三氟甲基硫化物的新方法。通过在 N,N-二甲基乙酰胺中结合 AgSCF3 和 NCS，产生了亲电活性中间体，然后用各种末端炔烃处理，以中等至极好的收率提供相应的三氟甲磺酰化产物。
• 10.1002/anie.202407689
  作者：Marie, Nicolas、Ma, Jun-An、Tognetti, Vincent、Cahard, Dominique

  DOI：10.1002/anie.202407689

  日期：——

  A photocatalyzed formal (3+2) cycloaddition has been developed to construct original polysubstituted α‐SCF3 cyclopentanones in a regio‐ and diastereoselective manner. This building block approach leverages trifluoromethylthio alkynes and branched / linear aldehydes, as readily available reaction partners, in consecutive hydrogen atom transfers and C–C bond formations. Difluoromethylthio alkynes are also compatible subtrates. Furthermore, the potential for telescoped reaction starting from alcohols instead of aldehydes was demonstrated, as well as process automatization and scale‐up under continuous microflow conditions. This prompted density functional theory calculations to support a free radical‐mediated cascade hydrogen atom transfer process.