Ethyl 4-cyano-3-methyl-5-({[(4-methyl-6-phenyl-2-pyrimidinyl)thio]acetyl}amino)-2-thiophenecarboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: Ethyl 4-cyano-3-methyl-5-({[(4-methyl-6-phenyl-2-pyrimidinyl)thio]acetyl}amino)-2-thiophenecarboxylate
• 英文别名: ethyl 4-cyano-3-methyl-5-[[2-(4-methyl-6-phenylpyrimidin-2-yl)sulfanylacetyl]amino]thiophene-2-carboxylate
• 化学式: C₂₂H₂₀N₄O₃S₂
• 分子量: 452.6
• InChiKey: DEWIMGKSXRQMOW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  31
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  159
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• HBV RNAse H purification and enzyme inhibitors
  申请人：Saint Louis University

  公开号：US10329542B2

  公开（公告）日：2019-06-25

  Provided herein are methods for the obtention of an active HBV RNaseH preparation and its use in screening methods to identify potential inhibitors of the enzyme for possible use as therapeutic agents. Also provided are methods of treatment using agents identified according to the screen.

  本文提供了获得活性 HBV RNaseH 制剂的方法及其在筛选方法中的应用，以确定可能用作治疗剂的潜在酶抑制剂。还提供了使用根据筛选确定的制剂进行治疗的方法。
• HBV RNASE H PURIFICATION AND ENZYME INHIBITORS
  申请人：Saint Louis University

  公开号：US20170335296A1

  公开（公告）日：2017-11-23

  Provided herein are methods for the obtention of an active HBV RNaseH preparation and its use in screening methods to identify potential inhibitors of the enzyme for possible use as therapeutic agents. Also provided are methods of treatment using agents identified according to the screen.