4-[[4-(4-Methoxyphenyl)phthalazin-1-yl]amino]benzoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-[[4-(4-Methoxyphenyl)phthalazin-1-yl]amino]benzoic acid
• 英文别名: 4-[[4-(4-methoxyphenyl)phthalazin-1-yl]amino]benzoic acid
• 化学式: C₂₂H₁₇N₃O₃
• 分子量: 371.4
• InChiKey: FPFGOBJZOGTCFT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  84.3
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• INHIBITORS OF ANANDAMIDE TRANSPORT AND THEIR THERAPEUTIC USES
  申请人：IIT - Istituto Italiano di Tecnologia

  公开号：US20140163034A1

  公开（公告）日：2014-06-12

  Nucleic acid and polypeptide sequences corresponding to FLAT, a partly cytosolic variant of the intracellular anandamide-degrading enzyme, fatty acid amide hydrolase-1 (FAAH-1), are provided. FLAT lacks amidase activity but binds the endocannibinoid anandamide and facilitates its transport into cells. A chemical scaffold for the inhibition of anandamide transport is identified. Compositions of the invention prevent anandamide internalization in vitro, interrupt anandamide deactivation in vivo, and cause profound CB 1 cannabinoid receptor-mediated analgesia in a mouse model of inflammatory pain. Accordingly, the invention also provides methods, and pharmaceutical compositions for treating conditions in which the modulation of anandamide transport would be of benefit.