N-[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]-6-propylsulfanyl-2H-benzotriazol-4-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并三唑类
• 英文名称: N-[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]-6-propylsulfanyl-2H-benzotriazol-4-amine
• 化学式: C₁₈H₁₈F₂N₄S
• 分子量: 360.4
• InChiKey: IELWDSXLWHBZRA-SWLSCSKDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  78.9
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Treating Cardiac Arrhythmias, Heart Failure, Peripheral Artery Disease and Stroke With Cyclopentyl-Triazolo-Pyrimidine or Derivative Thereof
  申请人：HearlDrug Research, L.L.C.

  公开号：US20140162970A1

  公开（公告）日：2014-06-12

  The present invention relates to new methods for treating and/or preventing cardiac arrhythmias, heart failure, stroke and/or peripheral artery disease by administering a composition comprising triazolopyrimidine, or derivative or metabolite thereof. In particular, the present invention relates to methods for treating cardiac arrhythmias, heart failure, stroke and/or peripheral artery disease by administering CycloPentyl-TriazoloPyrimidine.