N-Benzyl-1-phenyl-cyclohexylamin | 2201-51-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-Benzyl-1-phenyl-cyclohexylamin
• 英文别名: N-benzyl-1-phenylcyclohexan-1-amine
• CAS: 2201-51-6
• 化学式: C₁₉H₂₃N
• 分子量: 265.398
• InChiKey: QXDFOWJXUCIHGJ-UHFFFAOYSA-N

物化性质

• 沸点：
  145-150 °C(Press: 0.2 Torr)
• 密度：
  1.04±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  环己酮 以 苯 为溶剂， 反应 9.0h， 生成 N-Benzyl-1-phenyl-cyclohexylamin
  参考文献：
  名称：

  Metabolism of phencyclidine. The role of the carbinolamine intermediate in the formation of lactam and amino acid metabolites of nitrogen heterocycles

  摘要：

  The transformation of phencyclidine in a mouse liver microsome preparation to several oxidative metabolites was studied. With use of GLC and HPLC methods with internal standards, phencyclidine and six metabolites were quantitated and the amino acid 12, resulting from the alpha-oxidation of the piperidine ring, was produced in 10-50 times greater amounts than the other metabolites. While most piperidines and pyrrolidines produce an amino acid and a corresponding lactam, it was found that phencyclidine was not converted to the lactam 11.

  DOI：

  10.1021/jm00379a011

文献信息

• Metabolism of phencyclidine. The role of the carbinolamine intermediate in the formation of lactam and amino acid metabolites of nitrogen heterocycles
  作者：John K. Baker、Thomas L. Little

  DOI：10.1021/jm00379a011

  日期：1985.1

  The transformation of phencyclidine in a mouse liver microsome preparation to several oxidative metabolites was studied. With use of GLC and HPLC methods with internal standards, phencyclidine and six metabolites were quantitated and the amino acid 12, resulting from the alpha-oxidation of the piperidine ring, was produced in 10-50 times greater amounts than the other metabolites. While most piperidines and pyrrolidines produce an amino acid and a corresponding lactam, it was found that phencyclidine was not converted to the lactam 11.