(1R,7R)-4-(2,2,6,6-tetramethylpiperidin-1-yl)-9,9-dimethyl-2,2,6,6-tetrakis(3,5-dimethylphenyl)-3,5,8,10-tetraoxa-4-phosphabicyclo[5.3.0]decane | 1246496-32-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (1R,7R)-4-(2,2,6,6-tetramethylpiperidin-1-yl)-9,9-dimethyl-2,2,6,6-tetrakis(3,5-dimethylphenyl)-3,5,8,10-tetraoxa-4-phosphabicyclo[5.3.0]decane
• 英文别名: 1-[(3aR,8aR)-4,4,8,8-tetrakis(3,5-dimethylphenyl)-2,2-dimethyl-3a,8a-dihydro-[1,3]dioxolo[4,5-e][1,3,2]dioxaphosphepin-6-yl]-2,2,6,6-tetramethylpiperidine
• CAS: 1246496-32-1
• 化学式: C₄₈H₆₂NO₄P
• 分子量: 747.998
• InChiKey: NHWVNGIAVSFZIB-OCQXTOTRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.4
• 重原子数：
  54
• 可旋转键数：
  5
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  40.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  (1R,7R)-4-chloro-9,9-dimethyl-2,2,6,6-tetra(3,5-dimethylphenyl)-3,5,8,10-tetraoxa-4-phosphabicyclo[5.3.0]decane 、 2,2,6,6-tetramethylpiperidinyl-lithium 以 四氢呋喃 为溶剂， 以175 mg的产率得到(1R,7R)-4-(2,2,6,6-tetramethylpiperidin-1-yl)-9,9-dimethyl-2,2,6,6-tetrakis(3,5-dimethylphenyl)-3,5,8,10-tetraoxa-4-phosphabicyclo[5.3.0]decane
  参考文献：
  名称：

  Expeditious synthesis of TADDOL-derived phosphoramidite and phosphonite ligands

  摘要：

  A simple and reliable protocol for the synthesis of TADDOL-derived monodentate ligands is reported. The reaction of the requisite TADDOL with PCl3 is immediately followed by the treatment of the crude intermediate with both nitrogen and carbon nucleophiles. Several previously unknown or difficult-to-make phosphoramidite and phosphonite ligands L1-L3 and L4-L9 were accessed using this novel procedure. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2010.03.010

文献信息

• Expeditious synthesis of TADDOL-derived phosphoramidite and phosphonite ligands
  作者：Marius Mewald、Andreas Weickgenannt、Roland Fröhlich、Martin Oestreich

  DOI：10.1016/j.tetasy.2010.03.010

  日期：2010.5

  A simple and reliable protocol for the synthesis of TADDOL-derived monodentate ligands is reported. The reaction of the requisite TADDOL with PCl3 is immediately followed by the treatment of the crude intermediate with both nitrogen and carbon nucleophiles. Several previously unknown or difficult-to-make phosphoramidite and phosphonite ligands L1-L3 and L4-L9 were accessed using this novel procedure. (C) 2010 Elsevier Ltd. All rights reserved.